Affinity-based protein profiling (afbpp)

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Proteomics (17)
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Imperial College London (6)
Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching b. München 85747, Germany; Chair of Organic Chemistry II, Technische Universität München, Garching b. München 85747, Germany (1)
Department of Chemistry, Technische Universität München, Germany (1)
Farnusch Kaschani, Analytics Core Facility Essen (ACE), Chemische Biologie, Universität Duisburg-Essen, ZMB, Germany (1)
Lehrstuhl Organische Chemie II, Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching b. München (1)
Molecular Physiology, Leiden Institute of Chemistry, Leiden University, The Netherlands (1)
TUM Center for Functional Protein Assemblies (CPA), Department of Chemistry and Chair of Organic Chemistry II, Technical University of Munich, Lichtenbergstraße 4, 85748 Garching, Germany. (1)
TUM School of Natural Sciences, Department Biosciences, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University Munich (TUM), Ernst-Otto-Fischer Str. 8, Garching, 85748, Germany (1)
Technical University of Munich (1)
Technische Universität München Department of Chemistry Lehrstuhl Organische Chemie II Lichtenbergstr. 4 85747 Garching (bei München) (1)
Technische Universität München, Chair of Organic Chemistry,Garching, Germany (1)

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Affinity-based protein profiling (AfBPP) using different Callyaerin probes in M. tuberculosis H37Rv

The natural cyclopeptide Callyaerin B (CalB) exhibits highly specific antitubercular activity. The aim of this project is to study the protein binding partner of this compound using either activity-based protein profiling (ABPP) (ACE_0721) or affinity-based protein profiling (AfBPP) (ACE_0682 & ACE_...

ORGANISM(S): Mycobacterium tuberculosis H37Rv

2024-07-25 | PXD050770 | Pride

In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe.

Not available

S-EPMC11345752 | biostudies-literature

Affinity Based Protein Profiling of Fendiline Photoprobe in A. Baumannii

Competitive Affinity Based Protein Profiling of a Fendiline Photoprobe in A. Baumannii

ORGANISM(S): Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)

2025-12-15 | PXD056737 | Pride

Afbpp Antibiotics

Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus

To combat methicillin-resistant Staphylococcus aureus (MRSA) infections novel drugs are desperately needed. From a screen, we found that the anti-cancer drug sorafenib effectively kills MRSA strains. By synthetic variation of key structural features, we identified a potent analog, PK150, exhibiting ...

ORGANISM(S): Staphylococcus aureus

2019-09-09 | PXD012946 | Pride

Full proteome Affinity-based protein profiling (afbpp) Q exactive plus Chemical proteomics Staphylococcus aureus subsp. aureus nctc 8325 Secretome Surfaceome Orbitrap fusion

AfBPP of pyrrolopyrimidine α-helix mimetics

A wide range of small molecule scaffolds capable of mimicking protein α-helices to modulate protein-protein interactions have been reported, yet their target selectivity is poorly understood. Here, we report the affinity-based protein profiling of three structurally distinct classes of α-helix mimet...