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ProteomicsTissue proteome of visceral, subcutaneous and brown adipose as well as liver tissues in an obese mouse model after dietary exposure to the emerging phthalate substitute DINCH
Here, we analysed the global proteome of visceral, subcutaneous and brown adipose as well as liver tissues in a C57BL/6J mouse model of diet-induced obesity, following dietary exposure to 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH). This study includes data on male and female mice, as...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-03 | PXD054970 | Pride
Tissue proteomics Obesity Dinch Mouse 
ProteomicsEffects of MINCH exposure on the proteome of differentiating human SGBS adipocytes
Here, we evaluated the molecular effects of MINCH exposure, as primary metabolite of the DEHP substitute DINCH, on the proteome of differentiating SGBS adipocytes. This study includes data on rosiglitazone differentiated controls, 10 µM MINCH exposure, and exposure to the selective PPAR inhibitor GW...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD059428 | Pride
Adipogenesis Dinch Adipocytes Minch Sgbs Gw9662 Proteome 
ProteomicsEffects of MINCH exposure on the acetylome of differentiating human SGBS adipocytes
Here, we evaluated the molecular effects of MINCH exposure, as primary metabolite of the DEHP substitute DINCH, on the acetylome profiles of differentiating SGBS adipocytes. This study includes data on rosiglitazone differentiated controls, 10 µM MINCH exposure, and exposure to the selective PPAR in...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD059390 | Pride
Acetylome Adipogenesis Dinch Adipocytes Minch Sgbs Gw9662 
ProteomicsEffects of MINCH exposure on the phosphoproteome of differentiating human SGBS adipocytes
Here, we evaluated the molecular effects of MINCH exposure, as primary metabolite of the DEHP substitute DINCH, on the phosphoproteome profiles of differentiating SGBS adipocytes. This study includes data on rosiglitazone differentiated controls, 10 µM MINCH exposure, and exposure to the selective P...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD059416 | Pride
Adipogenesis Phosphoproteome Dinch Adipocytes Minch Sgbs Gw9662 
ProteomicsIdentification of potential protein interaction candidates of MINCH in SGBS adipocytes using Thermal Proteome Profiling (TPP)
Here, we identified potential protein interaction partners of MINCH, as primary metabolite of the phthalate DEHP substitute DINCH, in the human SGBS adipocyte cell line. This study includes data on the thermal stability of proteins upon incubation of the cell lysates with 10 µM MINCH at day 4, an ea...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD059386 | Pride
Sgbs adipocytes Thermal proteome profiling Tpp Minch Protein interaction partner 
ProteomicsEffects of dietary DINCH exposure on the proteome, phosphoproteome and acetylome of adipose tissue of a murine diet induced model of obesity
Here, we evaluated the molecular effects of dietary DINCH exposure, on the proteome, phosphoproteome and acetylome profiles of visceral and subcutaneous adipose tissue in a model of diet-induced obesity in male and female C57BL/6N mice. This study includes data on visceral and subcutaneous adipose t...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-05 | PXD059421 | Pride
Acetylome Phosphoproteome C57bl/6n mice Subcutaneous adipose tissue Diet induced obesity Proteome Visceral adipose tissue Dinch 
ProteomicsEffects of DINCH and MINCH exposure on the proteome of differentiating primary human stromal vascular fraction cells
Here, we evaluated the molecular effects of 10 nM and 10 µM DINCH and MINCH exposure on the proteome profiles of differentiating human primary SVF cells. The SVF cells derived from the subcutaneous adipose tissue of donors undergoing aesthetic surgery at abdomen, leg or back. The dataset comprised m...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD059419 | Pride
Human stromal vascular fraction Adipogenesis Dinch Subcutaneous adipose tissue Minch 
ProteomicsPhosphoproteome dynamics during differentiation of SGBS adipocytes
Here, we identified temporal dynamics of the phosphoproteome during adipocyte differentiation in the human SGBS cells, applying untargeted proteomics in combination with enrichment strategies for phosphorylated peptides. Samples were taken at initiation of differentiation, at an intermediate and ter...
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD045770 | Pride
Adipogenesis Adipocytes Phosphoproteome Temporal dynamics Sgbs 
ProteomicsPhosphoproteome dynamics during differentiation of 3T3-L1 adipocytes
Here, we identified temporal dynamics of the phosphoproteome during adipocyte differentiation in the murine 3T3-L1 cells, applying untargeted proteomics in combination with enrichment strategies for phosphorylated peptides. Samples were taken at initiation of differentiation, at an intermediate and ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-13 | PXD045778 | Pride
Adipogenesis 3t3-l1 Adipocytes Phosphoproteome Temporal dynamics 
ProteomicsProteome dynamics during differentiation of 3T3-L1 adipocytes
Here, we identified temporal dynamics in the proteome during adipocyte differentiation of the murine 3T3-L1 cells, applying untargeted proteomics. Samples were taken at initiation of differentiation, at an intermediate and terminal time point.
ORGANISM(S): Mus musculus (Mouse) 
2024-06-13 | PXD045772 | Pride
Adipogenesis 3t3-l1 Adipocytes Proteome Temporal dynamics 
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