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MetabolomicsSystem-level analysis of flux regulation of yeast show that glycolytic flux is controlled by allosteric regulation and enzyme phosphorylation
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST002397 | MetabolomicsWorkbench
GenomicsAllosteric regulation by c-di-AMP modulates global signal integration in Actinobacteria
Allosteric regulation by c-di-AMP modulates global signal integration in Actinobacteria
PRJNA956843 | ENA
GenomicsAllosteric and Energetic Remodeling by Protein Domain Extensions
Allosteric and Energetic Remodeling by Protein Domain Extensions
PRJEB90076 | ENA
ProteomicsHDX-MS of CHIP wt and K30A mutant
HDX-MS was used to establish that conformational-inhibition-signals extended from the TPR-domain to the U-box of CHIP. This underscores inter-domain allosteric regulation of CHIP by the core molecular chaperones. Defining the chaperone-associated TPR-domain of CHIP as a manager of inter-domain commu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-30 | MSV000079205 | MassIVE
ProteomicsFunctional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation.
Allosteric regulation is central to the role of the glycolytic enzyme pyruvate kinase M2 (PKM2) in cancer metabolism. Multiple activating and inhibitory allosteric ligands regulate PKM2 activity by controlling the equilibrium between high activity tetramers and low activity dimers and monomers. Howe...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD010334 | Pride
Srm Prm Pkm2 Quantitation Qexactive 
ProteomicsStructural mechanisms of allosteric regulation in the human cis-prenyltransferase complex
Human cis-prenyltransferase (hcis-PT) synthesizes long-chain isoprenoids essential for N-linked protein glycosylation. This heteromeric complex comprises the catalytic subunit DHDDS and the regulatory Nogo-B receptor (NgBR). Although NgBR dramatically enhances DHDDS activity, the molecular basis for...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD063722 | Pride
Nogo-b receptor Allosteric regulation Dehydrodolichyl diphosphate synthase Cis-prenyltransferase Dhdds N-linked glycosylation Molecular dynamics simulations Hydrogen-deuterium exchange mass spectrometry Network analysis Ngbr 
ModelsBulik2016 - Regulation of hepatic glucose metabolism
Bulik2016 - Regulation of hepatic glucose metabolism This model is described in the article: The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling. Bulik S, Holzhüt...
2024-09-02 | BIOMD0000000633 | BioModels
GenomicsAllosteric regulation by c-di-AMP modulates global signal integration in Actinobacteria
C-di-AMP is primarily associated with the regulation of carbon utilization as well as other central traits, central metabolism, and bacterial stringent response to environmental changes. Elevated c-di-AMP levels result in aberrant physiology for most c-di-AMP synthesizing organisms, drawing particul...
ORGANISM(S): Saccharopolyspora erythraea 
2024-03-31 | GSE229938 | GEO
GenomicsGlobal mapping of the energetic and allosteric landscapes of protein binding domains
Global mapping of the energetic and allosteric landscapes of protein binding domains
PRJNA762874 | ENA
ProteomicsStructural analysis of the regulatory GAF domains of cGMP phosphodiesterase elucidates the allosteric communication pathway
Regulation of photoreceptor phosphodiesterase (PDE6) activity is responsible for the speed, sensitivity, and recovery of the photoresponse during visual signaling in vertebrate photoreceptor cells. It is hypothesized that the physiological differences in the light responsiveness of rods and cones ma...
ORGANISM(S): Gallus gallus (Chicken) 
2022-02-15 | PXD020817 | Pride
Pde6 Allosteric regulation Chemical cross-linking Mass spectrometry Structural biology X-ray crystallography Nuclear magnetic resonance spectroscopy Integrative structural modeling 
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