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ProteomicsIntegrative structure models of the α-Synuclein dimer conformations
α-Synuclein is an intrinsically disordered protein known for its contributions to functions in neurons but mostly in its contributions to the development of Parkinson's disease via formation of self-associated forms, fibrils and Lewy bodies. Among the multiple targets it interacts with and gains a f...
ORGANISM(S): Homo sapiens (Human) 
2023-01-30 | PXD030299 | Pride
Α-synuclein Dimer Parkinson's Hetreo isotopic cl-ms 
TranscriptomicsExpression data of beta-subunit of Snf1 kinase in yeast Saccharomyces cerevisiae
The conserved Snf1/AMPK (AMP-activated protein Kinase) family is one of the central components in nutrient sensing and regulation of carbon metabolism in eukaryotes. It is also involved in several other processes such as stress resistance, invasive growth and ageing. Snf1 kinase is composed of a cat...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-27 | E-GEOD-20591 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiling of mitochondrial subunits in subjects with Parkinson’s disease
Introduction: Parkinson's disease (PD), typically developing between the ages of 55 and 65 years, is a common neurodegenerative disorder caused by a progressive loss of dopaminergic neurons due to the accumulation of α-synuclein in the substantia nigra. Mitochondria are known to play a key role in c...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-9950 | biostudies-arrayexpress
UnknownS-Acylation controls functional coupling of BK channel pore-forming α-subunits and β1-subunits.
Not available
S-EPMC6690687 | biostudies-literature
TranscriptomicsTranscription profiling of Drosophila wild type and bap170;bap180 double mutant reveals two PBAP chromatin remodeling complex-specific subunits have distinct, redundant functions during development
Chromatin remodeling complexes control the availability of DNA binding sites to transcriptional regulators. Two distinct forms of the major SWI/SNF-related complex that have different activities in vitro can be distinguished by the presence of specific accessory subunits. In Drosophila, the core Bra...
ORGANISM(S): Drosophila melanogaster 
2009-10-21 | E-GEOD-11825 | biostudies-arrayexpress
UnknownNonmuscle myosin II isoforms interact with sodium channel alpha subunits.
Not available
S-EPMC6052497 | biostudies-literature
ProteomicsAbsolute quantification of human milk caseins and the whey/casein ratio during the first year of lactation
Whey proteins and caseins in breast milk provide bioactivities and also have different amino acid composition. Accurate determination of these two major protein classes will therefore provide a better understanding of human milk composition and function and also aid in developing improved infant for...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-06-23 | MSV000081195 | MassIVE
ProteomicsFunctional Asymmetry and Essential Structural Roles of PDE6α and PDE6β Subunits in Rod Photoreceptor Integrity
Tetrameric rod phosphodiesterase 6 (PDE6) critically regulates cyclic GMP (cGMP) levels in rod photoreceptors comprised of catalytic core α/β heterodimer and two small inhibitory γ subunits. While the rod PDE6 catalytic core is a heterodimer, the cone isoform is an α'/α' homodimer. This structural d...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD073183 | Pride
Cgmp Phosphodiesterase 6 Outer segment Rod photoreceptor Visual transduction 
UnknownComparative analysis of eubacterial DNA polymerase III alpha subunits.
Not available
S-EPMC5054071 | biostudies-literature
UnknownEmerging evidence for specific neuronal functions of auxiliary calcium channel α₂δ subunits.
Not available
S-EPMC4487825 | biostudies-literature
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