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ProteomicsIdentification of di-Boron cleavage events at Dha residues on recombinant protein in e.coli lysate
Neurokinin-A (NKA) is only active when its C-terminus is amidated. B2(OH2) is thought to interact with Dha and cleave the peptide, leaving the amide on the C-terminus of the left-hand peptide. PeptideID MS/MS experiment was performed in e.coli lysate with overevpressed recombinant NKA-eH3 to prove d...
ORGANISM(S): Escherichia coli 
2022-05-19 | PXD030233 | Pride
Chemical cleavage Dha Amidated c-term 
UnknownRationally engineered active sites for efficient and durable hydrogen generation.
Not available
S-EPMC6533258 | biostudies-literature
MetabolomicsNeuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

The gut microbiome has been associated with pathological neurophysiological evolvement in extremely premature infants suffering from brain injury. The exact underlying mechanism and its associated metabolic signatures in infants are not fully understood. To decipher metab...

2023-12-30 | MTBLS7560 | MetaboLights
ProteomicsHuman plasma peptidomics - Identification and quantification of plasma free salusin-β, an endogenous parasympathomimetic peptide
We have improved our ultrahigh-yield method, which we named “differential solubilization" (J Proteome Res 9, 2010, 1694-1705), to extract and analyse low-molecular-weight plasma peptides, and initiated a large-scale sequencing of circulating native peptides at concentrations as low as the picomolar ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003533 | Pride
Plasma Native peptide Peptidome 
ProteomicsCharacterization of the venom proteome of the emerald jewel wasp, Ampulex compressa
Characterization of the venom proteome of the emerald jewel wasp, Ampulex compressa
ORGANISM(S): Ampulex compressa 
2019-01-07 | PXD006340 | Pride
Ampulex compressa venom venome 
ProteomicsAncient origin and dynamic evolution of bivalent spider toxins
Bivalent peptide toxins comprising two cysteine-rich domains have evolved from single-domain precursors on multiple occasions in animal venoms, resulting in enhanced molecular target selectivity and avidity. Although bivalent toxins are emerging as prevalent in animal venoms, the genomic and evoluti...
ORGANISM(S): Lasiodora parahybana Fufius Hadronyche cerberea Chaetopelma olivaceum Cyrtocarenum grajum Brachypelma boehmei Avicularia avicularia Chilobrachys Harpactira 
2026-06-08 | PXD070138 | Pride
Australian funnel-web spider Inhibitor cystine knot Pi-hexatoxin Hi1a Spider venom Bivalent peptides Mygalomorphae 
ProteomicsMultiple Evolutionary Mechanisms Underlie the Venom Composition of the Green Lacewing
Venom has independently evolved across many lineages, yet relatively few have been studied in detail, particularly among insects. Of these, Neuroptera (lacewings, antlions and relatives) remain largely unexplored, despite being widespread with agriculturally important groups such as green lacewings....
ORGANISM(S): Chrysoperla carnea 
2026-01-12 | PXD070278 | Pride
Venom 
ProteomicsN-glycosite mapping in Brugia malayi female worms, male worms, and microfilariae
N-linked glycosylation is a critical post translational modification of eukaryotic proteins. N-linked glycans are present on surface and secreted filarial proteins that play a role in host parasite interactions. Examples of glycosylated Brugia malayi proteins have been previously identified but ther...
ORGANISM(S): Brugia malayi 
2023-04-23 | PXD039002 | Pride
Lc-msms N-glyco fasp Filarial parasite 
ProteomicsRed Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude
High altitude conditions improve glucose tolerance and reduce diabetes risk, but the physiological mechanism is not well-understood. Using mouse models, we found that hypoxia alone robustly improved glucose tolerance and that the effect persisted for weeks after returning to normal oxygen levels. PE...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD071719 | Pride
Red blood cells Cross-linking Hypoxia 
ProteomicsProteomic analysis of Kveim reagent identifies targets of cellular immunity in sarcoidosis
Kveim-reagent (Kv) skin testing was a historical method of diagnosing sarcoidosis. Intradermal injection of treated sarcoidosis spleen tissue resulted in a granuloma response at injection site by 4-6 weeks. Previous work indicates proteins as the possible trigger of this reaction. We aimed to identi...
ORGANISM(S): Homo sapiens (Human) 
2017-01-31 | PXD005150 | Pride
Interstitial lung diseases Sarcoidosis Immunology Proteomics 
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