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ProteomicsMICU3 Plays an Important Role in Cardiovascular Function
Mitochondrial calcium regulates bioenergetics but also serves as a trigger for cell death.1 With a sustained increase in catecholamine or a large increase in cytosolic calcium as occurs with ischemia, mitochondrial calcium can rise to high levels, leading to activation of the mitochondrial permeabil...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-11-23 | MSV000088439 | MassIVE
TranscriptomicsTranscriptomic analysis reveals the involvement of canonical Wnt signaling in zebrafish gonad differentiation
Zebrafish males undergo a juvenile ovary to testis type gonadal transformation process. To understand how juvenile ovary-to-testis transformation in zebrafish is genetically regulated, we compared the transcriptomes of juvenile ovary (JO) and juvenile ovotestis (JOT) samples at 35 dpf using the Gona...
ORGANISM(S): Danio rerio 
2013-12-27 | E-MEXP-3879 | biostudies-arrayexpress
ProteomicsAutoGP 2: an improved fully automated high-throughput system for simultaneously enriching and separating intact glycopeptides
An improved fully automated high-throughput system, named as AutoGP 2, for simultaneously enriching and separating intact glycopeptides has been developed in this study by introducing a second 10-port valve (valve 2) to the previously developed AutoGP system with only a 10-port valve (valve 1). Spec...
ORGANISM(S): Mus Musculus 
PXD069435 |
ProteomicsProteomic analyses of embryogenic tissues in Picea balfouriana treated by 6-BAP
In this study, iTRAQ technology was applied to characterize the genes and proteins that are differentially expressed among tissues under the influence of different levels of 6-BAP(2.5 μM, 3.6 μM and 5 μM). There were two biological and three technological replicates for each treatment. Two biologica...
ORGANISM(S): Picea likiangensis var. rubescens 
2014-09-23 | PXD001022 | Pride
Picea balfouriana 6-bap Embryogenic tissues Lc-ms/ms 
ProteomicsGlobal lysine acetylome analysis of Picea asperata somatic 1 embryos during partial desiccation
By the combination of affinity enrichment and high-resolution LC-MS/MS analysis, large-scale lysine acetylome analysis was performed in picea asperata. Altogether, 1,360 lysine acetylation sites in 717 protein groups were identified. Intensive bioinformatic analysis was then carried out to annotate ...
ORGANISM(S): Picea asperata 
2018-10-26 | PXD005042 | Pride
Picea asperata Acetylome Lc-msms 
ProteomicsMass spectrometry analysis of post-translational modifications of K/C-III-expressing HEK293T cells treated by A485 for 6 and 12 hours
To determine whether CBP/P300 HAT activity is essential for leukemia cell maintenance, we utilized the selective acetyltransferase inhibitor A485. Mass spectrometry analysis of post-translational modifications showed that A485 treatment of K/C-III-expressing HEK293T cells for 6 and 12 hours signific...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD061565 | Pride
Human A485 Post-translational modification K/c-iii Lc-faims-ms/ms 
ProteomicsQuantitative phosphoproteomic and physiological analyses provide insights into the formation of the variegated leaf in Catalpa fargesii
To unveil the role of posttranslational modification in the variegated phenotype, we conducted global quantitative phosphoproteomic analysis on different leaf color sectors of Maiyuanjinqiu and the corresponding of Catalpa fargesii using Ti4+-IMAC phosphopeptide enrichment. 3778 phosphorylated sites...
ORGANISM(S): Catalpa fargesii 
2019-11-12 | PXD013065 | Pride
Catalpa fargesii  phosphoproteomics  variegated leaf  regulated mechanism 
ProteomicsInhibition Peroxiredoxin-2 by capsaicin ameliorates rheumatoid arthritis via ROS-mediated apoptosis in fibroblast-like synoviocytes
In this project we discovered that CAP not only reduces joint swelling in arthritic model mice but also exhibits anti-inflammatory and antiproliferative effects on fibroblast-like synoviocytes (FLS). By synthesizing alkyne-tagged CAP probes and employing activity-based protein profiling (ABPP), we i...
ORGANISM(S): Homo Sapiens 
2024-11-12 | PXD057819 |
Proteomicscapsaicin ameliorates rheumatoid arthritis via ROS-mediated apoptosis in fibroblast-like synoviocytes
In this project we discovered that CAP not only reduces joint swelling in arthritic model mice but also exhibits anti-inflammatory and antiproliferative effects on fibroblast-like synoviocytes (FLS). By synthesizing alkyne-tagged CAP probes and employing activity-based protein profiling (ABPP), we i...
ORGANISM(S): Homo Sapiens 
2024-11-07 | PXD057639 |
ProteomicsImmunoprecipitation and mass spectrometry (IP-MS) on KAT6A chimeras
Despite KAT6A chimeras potent oncogenic activity, the mechanisms by which KAT6A fusion proteins achieve genomic specificity and drive leukemogenesis remain poorly understood. Previous studies suggest that the leukemogenic potential of KAT6A-TIF2 depends on its chromatin-binding ability rather than i...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD061491 | Pride
Human Ip-ms. Kat6a fusion Immunoprecipitation Kat6a n-terminus 
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