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ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Homo sapiens (Human) 
2026-04-17 | PXD069216 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-17 | PXD069221 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-17 | PXD069222 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Homo sapiens (Human) 
2026-04-17 | PXD069192 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration.
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-17 | PXD069175 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration.
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Homo sapiens (Human) 
2026-04-17 | PXD069174 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
TranscriptomicsFunctional tissue specific MSC in lung-transplanted patients with and without bronchiolitis obliterans syndrome (BOS) - a potential source for cell-therapy?
Background: Mesenchymal stromal cells (MSC) have been proposed as a future cell based therapy for lung diseases like bronchiolitis obliterans syndrome (BOS). Theoretically, it might be beneficial to use lung resident MSC already adapted to the pulmonary environment. We therefore aimed to compare lun...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-74163 | biostudies-arrayexpress
ProteomicsDissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells, IGF2-GGCT Lysate
The transcription factor ZBED6 acts as a repressor of Igf2 and affects directly or indirectly the transcriptional regulation of thousands of genes. Here, we use gene editing in mouse C2C12 myoblasts and show that ZBED6 regulates Igf2 exclusively through its binding site 5′-GGCTCG-3′ in intron 1 of I...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-07 | PXD012789 | Pride
Zbed6 Silac Igf2 Mitochondria Myogenesis 
ProteomicsDissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells, ZBED6-KO Lysate
The transcription factor ZBED6 acts as a repressor of Igf2 and affects directly or indirectly the transcriptional regulation of thousands of genes. Here, we use gene editing in mouse C2C12 myoblasts and show that ZBED6 regulates Igf2 exclusively through its binding site 5′-GGCTCG-3′ in intron 1 of I...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-07 | PXD012757 | Pride
Zbed6 Silac Igf2 Mitochondria Myogenesis 
ProteomicsDissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells, ZBED6-KO Medium
The transcription factor ZBED6 acts as a repressor of Igf2 and affects directly or indirectly the transcriptional regulation of thousands of genes. Here, we use gene editing in mouse C2C12 myoblasts and show that ZBED6 regulates Igf2 exclusively through its binding site 5′-GGCTCG-3′ in intron 1 of I...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-07 | PXD012769 | Pride
Zbed6 Silac Igf2 Mitochondria Myogenesis 
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