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ProteomicsGSE1 is a prominent interactor of HDAC1
We analysed the composition of histone acetylase 1 (HDAC1)-associated proteins in different cellular backgrounds using quantitative mass spectrometry (MS). First, we affinity purified (AP) C-terminally FLAG-tagged HDAC1 from the nearly haploid human cell line HAP1 (Andersson et al, 1987). To examine...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-10-23 | PXD040307 | Pride
Mef Hdac1 Gse1 Hap1 Dna damage response Interactome 
ProteomicsDeletion of GSE1 and HDAC1 inactivation alters proteomic profiles and cell cycle control
The DNA damage response (DDR) is orchestrated by multiple, tightly regulated signalling events. We discovered that genetic suppressor element 1 (GSE1) forms a complex with the histone deacetylation 1 (HDAC1) / CoREST complex and that loss of GSE1 hampers DDR induction. To investigate how GSE1 and HD...
ORGANISM(S): Homo sapiens (Human) 
2023-10-23 | PXD040339 | Pride
Acetylome Hdac1 Gse1 Phosphorylome Hap1 Dna damage response 
TranscriptomicsTranscription profiling of Arabidopsis apices from control and smz-D flc-3 knock-out plants after photoperiod induction
Response of control (flc-3) and dominant late flowering mutant (smz-D flc-3) to inductive photoperiod (tissue: apices)
ORGANISM(S): Arabidopsis thaliana 
2009-06-05 | E-MEXP-2041 | biostudies-arrayexpress
TranscriptomicsRNAseq of iPSC derived cardiomyocytes in response to endothelin-1 as a model for cardiac hypertrophy
The study aims to develop an in vitro model of cardiac hypertrophy using human induced pluripotent stem cells (hPSCs). Human stem cell based disease models are important for reducing the number of animals used in research and to get data the is more relevant to humans. We stimulated hiPSCs derived c...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-8548 | biostudies-arrayexpress
GenomicsGlioma GWAS summary statistics
Meta-analysis association statistics from case-control analysis (includes imputed SNPs)
EGAD00010001657 | EGA
GenomicsSummary statistics from genome-wide association study in glioma of 12,488 cases and 18,169 controls.
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,488 cases and 18,169 controls. We identified five ...
EGAS00001003372 | EGA
GenomicsGlioma GWAS summary statistics DAC
Data Access Committee EGAC00001001116
EGAC00001001116 | EGA
UnknownLong-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial.
Not available
S-EPMC4322188 | biostudies-literature
UnknownIntraoperative transfusion practices in Europe.
Not available
S-EPMC4718146 | biostudies-literature
UnknownUpdate on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited.
Not available
S-EPMC3286387 | biostudies-literature
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