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The DNA damage response (DDR) is orchestrated by multiple, tightly regulated signalling events. We discovered that genetic suppressor element 1 (GSE1) forms a complex with the histone deacetylation 1 (HDAC1) / CoREST complex and that loss of GSE1 hampers DDR induction. To investigate how GSE1 and HD...
ORGANISM(S): Homo sapiens (Human) 
2023-10-23 | PXD040339 | Pride
Here, we developed a conjoint analysis and systematic clustering method to explore the intermodification communications between succinylome and phosphorylome from 8 lung cancer patients.
ORGANISM(S): Homo Sapiens 
2023-09-15 | PXD045413 |
Nowadays, high-throughput quantitative proteomic and transcriptomic approaches have been widely used for exploring molecular mechanisms and acquiring biomarkers for cancers. Our study aims to illuminate the multi-dimensional molecular mechanisms underlying renal cell carcinoma via investigating the ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025551 | Pride
The aim of this project is to use an integrated approach involving SILAC labeling, HPLC fractionation, Phospho(STY) antibody affinity enrichment, LC-MS/MS to quantify the dynamic changes of the whole phosphorylome in the control and experimental samples.
ORGANISM(S): Mus musculus (Mouse) 
2018-10-27 | PXD004687 | Pride
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