This series represents a group of cutaneous malignant melanomas and unrelated controls which were clustered based on correlation coefficients calculated through a comparison of gene expression profiles. Keywords: other
The DNA damage response (DDR) is orchestrated by multiple, tightly regulated signalling events. We discovered that genetic suppressor element 1 (GSE1) forms a complex with the histone deacetylation 1 (HDAC1) / CoREST complex and that loss of GSE1 hampers DDR induction. To investigate how GSE1 and HD...
We analysed the composition of histone acetylase 1 (HDAC1)-associated proteins in different cellular backgrounds using quantitative mass spectrometry (MS). First, we affinity purified (AP) C-terminally FLAG-tagged HDAC1 from the nearly haploid human cell line HAP1 (Andersson et al, 1987). To examine...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)
The A549 cell line is often used as a model for human lung adenocarcinoma, and thus, insights gained from studies using these cells can be valuable for understanding lung cancer biology. The gene of interest, GSE1, may play a crucial role in regulating various cellular functions. By knocking down GS...
Background: Lung cancer, particularly lung adenocarcinoma, remains one of the most lethal malignancies globally. Identifying aberrant molecular pathways and potential therapeutic targets is pivotal for improving patient outcomes. This study focused on the role of GSE1 (genetic suppressor element 1) ...
