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MetabolomicsBiological Potential of Lophosoria quadripinnata Fern Extract: Integration of UHPLC/ESI/QToF/MS Analysis, Antioxidant Activity, Molecular Docking and Molecular Dynamics Simulation

Lophosoria quadripinnata (J.F.Gmel.) C.Chr., a fern species from the Dicksoniaceae family, is widely distributed in Central and South America. This study aimed to identify the bioactive compounds in the aqueous extract of L. quadripinnata, evaluate its antioxidant potential through in vitro analy...

2025-06-27 | MTBLS9336 | MetaboLights
TranscriptomicsTranscription profiling of human neuroblastoma cell line IMR-32 overexpressiong SQSTM1 and DPP3 to identify activators for the antioxidant response element
The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found in the 5’ flanking region of many phase II detoxification enzymes. Upregulation of ARE-dependent target genes is known to have neuroprotective effects; yet, the mechanism of activation is largely unknown. By scr...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6451 | biostudies-arrayexpress
MetabolomicsEffect of heat stress on serum enzyme activity, antioxidant capacity and immune parameter metabolomics datasets in Holstein cows at different growth stages

Global climate change has led to an increase in release of atmospheric CO2 and average daily temperatures, making heat stress a major challenge in dairy farming. The present study aimed to investigate metabolite changes of Holstein cows at different stages. In this experiment, 10 growing heifers,...

2022-08-11 | MTBLS5148 | MetaboLights
TranscriptomicsRole of thioredoxin reductase in the Yap1p-dependent response to oxidative stress
The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. To identify factors that regulate Yap1p activity, we carried out a genetic screen for mutants that show elevated expression ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-07-22 | E-GEOD-2977 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mutations in the yeast TRR1 gene encoding thioredoxin reductase
The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. To identify factors that regulate Yap1p activity, we carried out a genetic screen for mutants that show elevated expression ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-06-30 | E-SMDB-2716 | biostudies-arrayexpress
ProteomicsEFFECTS OF ERYTHRODIOL ON THE ANTIOXIDANT RESPONSE AND PROTEOME OF HepG2 CELLS
Erythrodiol (EO) is a pentacyclic triterpenic alcohol found in the leaf of olive tree and in the olive oil. In this study, we evaluate the nature of cytotoxicity of EO on HepG2 hepatocarcinoma human cells studying the changes induced on cell viability, reactive oxygen species (ROS) production, antio...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029865 | Pride
Gsh Ros Erythrodiol Antioxidant enzymes Nadph Proteome Hepg2 Cytotoxicity 
ProteomicsReactive oxygen species (ROS) production triggers unconventional secretion of antioxidant enzymes
Nutrient deprivation triggers the release of signal-sequence-lacking antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other antioxidant enzymes such as thioredoxins, (Trx1 and Trx2) and peroxiredoxin Ahp1. Our data reveal...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-03-26 | PXD016815 | Pride
Proteomics Yeast Ros 
ProteomicsLolium perenne green juice fractionated
In this study, the ex vivo antioxidant activity of fractionated L. perenne green juice protein is investigated, and responsible effectors are evaluated. Moreover, the study provides the first comprehensive proteomic analysis of L. perenne and provides insights on the fate of individual proteins duri...
ORGANISM(S): Lolium perenne subsp. perenne 
2025-05-07 | PXD058237 | Pride
Perennial ryegrass Sec fractionation Antioxidant enzymes 
ProteomicsMelatonin promotes chilling tolerance of cucumber seedlings by regulating antioxidant systems and relieving photoinhibition
Chilling is a major stress which adversely decreases photosynthesis and leads to oxidative stress in thermophilic plants. The role of melatonin (MT) in stress response of plants, has so far been investigated, while the mechanisms by which MT regulate photosynthesis in chilling-sensitive cucumber und...
ORGANISM(S): Cucumis sativus 
2022-02-15 | PXD029134 | Pride
Melatonin Reactive oxygen Antioxidant system Photosynthesis Chilling stress Cucumber 
GenomicsMicrofluidic Co-Encapsulation of Exosomal miRNAs and Antioxidant Enzymes Ameliorates Hepatic Steatosis by Driving M2 Polarization and Reparative Neutrophil Recruitment
Microfluidic Co-Encapsulation of Exosomal miRNAs and Antioxidant Enzymes Ameliorates Hepatic Steatosis by Driving M2 Polarization and Reparative Neutrophil Recruitment
PRJNA1505513 | ENA
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