Sort   by:  
 Page size 
MetabolomicsUntargeted serum metabolomics of dairy goats under heat stress and melatonin supplementation
Serum untargeted metabolomic profiling was performed to characterize metabolic alterations induced by heat stress and to evaluate the potential protective effects of melatonin supplementation in dairy goats. Serum samples were collected from dairy goats assigned to three experimental groups: a norma...
2026-09-10 | MTBLS15437 | MetaboLights
MetabolomicsMelatonin enhances function of porcine immature Sertoli cells via modulating gene expression and metabolism

Melatonin (MT), a neurohormone synthesized and secreted primarily by the pineal gland, is of vital function to animal reproduction. However, the effect of MT treatment on porcine immature Sertoli cells (iSCs) remains unclear. Here, MT treatment (10 nM, 36 h) could elevate mitochondrial function a...

2025-01-06 | MTBLS11126 | MetaboLights
TranscriptomicsMelatonin enhances plant growth and abiotic stress tolerance in soybean plants
Melatonin is a well-known agent that plays multiple roles in animals. Its possible function in plants is less clear. In the present study, we tested the effect of melatonin (N-acetyl-5-methoxytryptamine) on soybean growth and development. Both spraying of leaves and seed-coating with melatonin signi...
ORGANISM(S): Glycine max 
2014-08-31 | E-GEOD-57960 | biostudies-arrayexpress
ProteomicsMelatonin targets mitochondrial trifunctional enzyme HADHA to improve lipid metabolism in metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a clinicopathological syndrome characterized by abnormal accumulation of fat within hepatocytes, and there is currently no standardized clinical treatment available. Consequently, there is an urgent need to discover new pharmacologi...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD071550 | Pride
Melatonin Lipid metabolism Non-alcoholic steatotic liver disease 
ModelsBrown1997 - Plasma Melatonin Levels
Brown1997 - Plasma Melatonin Levels A mathematical model that incorporates a piecewise function for NAT activity to predict melatonin concentration. This model is described in the article: A mathematical model of diurnal variations in human plasma melatonin levels. Brown EN, Choe ...
2024-09-02 | BIOMD0000000672 | BioModels
ModelsPeng2013-melatonin--effects of light and routes of administration
Physiologically based pharmacokinetic (PBPK) models were developed using MATLAB Simulink(®) to predict diurnal variations of endogenous melatonin with light as well as pharmacokinetics of exogenous melatonin via different routes of administration. The model was structured using whole body, including...
2020-03-20 | MODEL2003190006 | BioModels
ProteomicsProteomic profile of two different cerebral hypoxic models treated with antioxidant melatonin and nitric oxide donors
In the present work we analyse the proteomic profile of two models of cerebral hypoxia with different severity as well as their response after treatment with the antioxidant melatonin and the nitric oxide-donor isosorbide mononitrate (ISMN).
ORGANISM(S): Rattus norvegicus (Rat) 
2017-07-17 | PXD004091 | Pride
Hypoxia Ischemia No donor Brain Tmt Rat Melatonin 
ProteomicsProteomic analysis reveals the neurotoxic effects of chronic methamphetamine self-administration-induced cognitive impairments and the role of melatonin-enhanced restorative process during drug withdrawal.
, this study aimed to investigate the mechanisms underlying neuropathological processes related to cognitive impairment in mice chronically-treated with METH. In addition, the effective melatonin on recovery of neurological dysfunction and neurobehavioral deficits during METH withdrawal was also inv...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD043828 | Pride
Mitophagy Cognitive function Methamphetamine Neurotoxicity Mitochondria Neuroplasticity Drug addiction Neurodegeneration Proteomics. Melatonin 
ProteomicsProteomic analysis reveals the effects of melatonin on soybean root tips under flooding stress
To interpret the melatonin-mediated flooding response in soybeans, proteomic analysis was performed in root tips.
ORGANISM(S): Glycine max 
2020-12-07 | PXD022450 | Pride
Flooding  melatonin  proteomics  root tip  soybean 
ProteomicsMelatonin confers saline-alkali tolerance by relieving nitrosative damage and S-nitrosylation of plasma membrane H+-ATPase 2 in tomato
Soil salination and alkalization are global problems impairing plant survival by disrupting REDOX homeostasis. Whether melatonin regulates REDOX homeostasis at nitrosative level, and thus affects plant saline-alkali tolerance remains unknown. In saline-alkali stress, excess nitric oxide (NO) causes ...
ORGANISM(S): 'Solanum lycopersicum' phytoplasma 
2025-04-28 | PXD056815 | Pride
Melatonin  nitric oxide  plasma membrane h+-atpase 2  saline-alkali stress  s-nitrosylation  tomato 
Sort   by:  
 Page size