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Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanism neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purification to isolate stable multi-protein complexes of...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021368 | Pride
Studying the phosphorylation events related to LMTK3 and its associated proteins in the brain. LMTK3 appears to be associated with the excitatory and inhibitory synaptic machinery, therefore this study was carried out to examine it's role in modulating inhibitory synapses.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-22 | PXD050212 | Pride
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that limits viral pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human and mouse models, we demonstrate that IFITM3 promotes MyD88-dependent, TLR-mediated IL-6 production following exposure...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-28 | PXD035254 | Pride
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