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Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
TranscriptomicsTargeted chromatin profiling reveals novel enhancers in Ig heavy and light chain loci.
Chip-chip from pro-B cells from Rag1KO mice for H3K27ac and RNA Pol II Identification of novel enhancers from Ig heavy and light chain loci Rag1KO pro-B epigenetic landscape at Ig heavy and light chain loci
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-53766 | biostudies-arrayexpress
TranscriptomicsComparing the biological impact of glatiramer acetate with the biological impact of a generic.
For decades, policies regarding generic medicines have sought to provide patients with economical access to safe and effective drugs, while encouraging the development of new therapies. This balance is becoming more challenging for physicians and regulators as biologics and non-biological complex dr...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-61901 | biostudies-arrayexpress
ProteomicsAtypical efferocytosis of live neutrophils dysregulates inflammation during P. gingivalis infection
Here, we show that neutrophils infected with the bacterial pathogen Porphyromonas gingivalis (Pg) are internalized alive by macrophages in a manner that bypasses all known efferocytic receptor-ligand interactions with highly inflammatory outcomes. Mechanistically, proteolytic cleavage of neutrophil ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD051073 | Pride
Immune evasion Macrophage Neutrophil Efferocytosis Bacterial protease 
Proteomics,MultiomicsElectrophilic stress induced by itaconate and its derivatives regulates ATF3-IKBZ inflammatory axis independently of Nrf2 induction
Metabolic regulation recently emerged as a novel powerful principle guiding immune responses. The natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) were recently shown to selectively inhibit a subset of cytokines during macrophage activation, yet the precise ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-25 | MSV000082101 | MassIVE
TranscriptomicsType 1 interferons induce changes in core metabolism that are critical for immune function
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress
ProteomicsUsing FAIMS to improve tumor neoantigen detection
DDA and PRM analysis, with and without FAIMS, for the T3, F244, and 1956 MCA sarcoma cell lines. PRM analysis of MHC-I neoantigens in ex vivo mouse tumors.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-08-08 | MSV000092617 | MassIVE
UnknownMyeloid cell interferon responses correlate with clearance of SARS-CoV-2.
Not available
S-EPMC8814034 | biostudies-literature
UnknownSingle-cell analyses of Crohn's disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions.
Not available
S-EPMC7997960 | biostudies-literature
UnknownHeterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.
Not available
S-EPMC8448524 | biostudies-literature
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