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UnknownGlycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel.
Not available
S-EPMC10015461 | biostudies-literature
UnknownSynthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β-Cyclodextrin Carrier for Nucleosides and Nucleotides.
Not available
S-EPMC10975686 | biostudies-literature
UnknownTranscriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis.
Not available
S-EPMC7355575 | biostudies-literature
TranscriptomicsGene expression profiles of hepatocyte-like cells derived from induced pluripotent stem cells (iPSCs) from donors with the Zellweger spectrum of peroxisome biogenesis disorders (PBD-ZSD) and healthy controls
Skin fibroblasts from individuals with PBD-ZSD, a rare autosomal recessive disorder caused by peroxisome assembly defects, show defects in lipid metabolism that provide the basis for clinical diagnostic tests, but are not among the cell types most affected by disease. To explore phenotypes of more c...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-69066 | biostudies-arrayexpress
UnknownInhibition of hepatitis B virus and induction of hepatoma cell apoptosis by ASGPR-directed delivery of shRNAs.
Not available
S-EPMC3477153 | biostudies-literature
TranscriptomicsHL-1 cardiomyocyte response to hypoxia
Expression profiling of cultured HL-1 cardiomyocytes subjected to hypoxia for 8 hours. Three samples from each condition were analyzed
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27975 | biostudies-arrayexpress
UnknownTargeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR).
Not available
S-EPMC6535107 | biostudies-literature
ProteomicsGlycan-based Biological Degraders Targeting the Cytokine Immune Axis
The project investigates targeted degradation of IL-6 and sIL6-R using bispecific Biological Degraders (BioDegs) that enable receptor-mediated uptake via the asialoglycoprotein receptor (ASGPR). Various IL-6(R)–binding scaffolds were modified with triantennary N-acetylgalactosamine (TGN) to promote ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD075514 | Pride
Asgpr Targeted protein degradation Biological degraders Tri-n-acetylgalactosamine Lysosomal degradation Il-6 Sil-6r 
ProteomicsImpact of asialoglycoprotein receptor and mannose receptor deficiency on murine plasma N-glycome profiles
The asialoglycoprotein receptor (ASGPR) and the mannose receptor 1 (MRC1) are C-type lectins that identify and remove glycoproteins from circulation. ASGPR recognizes terminal galactose and N-acetylgalactosamine, whereas MRC1 recognizes terminal mannose, fucose, and N-acetylglucosamine. The effects ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD042269 | Pride
Asialoglycoprotein receptor Glycomics Clearance Proteomics Mannose receptor 
TranscriptomicsStudy of transcriptional content in exosomes derived from untreated and growth factor-treated cultured cardiomyocytes (HL-1)
Introduction: Exosomes are nano-sized extracellular vesicles, released from various cells, which can stimulate or repress responses in target cells. We have recently shown that cultured cardiomyocytes release exosomes and that they, in turn, are involved in facilitating events in target cells by alt...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-40503 | biostudies-arrayexpress
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