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ProteomicsIsolation and mass spectrometry analysis of ATG9A vesicles from HAP1 cells.
Autophagy is a conserved cellular degradation pathway involving the formation of double-membrane autophagosomes that engulf cytoplasmic material for delivery to the lysosome. Autophagy-related (ATG) proteins orchestrate the steps of autophagosome formation and maturation, among which ATG9A is unique...
ORGANISM(S): Homo sapiens (Human) 
2026-08-04 | PXD066668 | Pride
Human Hap1 cells Atg9a vesicles 
ProteomicsSynaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like properties. We show that unlike synaptophysin, other major integral SV membrane proteins fail to form condensa...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2022-12-24 | PXD037490 | Pride
Synaptophysin Synapsin Atg9a Sypnatic vesicle 
UnknownATG9A vesicles are a subtype of intracellular nanovesicle.
Not available
S-EPMC12045599 | biostudies-literature
ProteomicsATG9A TurboID - ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair
Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving ER-lysosome membrane contact sites, phosphatidylinositol 4-kinase-2a (PI4K2A), phosphatidylinositol-4 phosphate (PI4P) and oxysterol-binding protein-related proteins (ORPs) li...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD056417 | Pride
Arfip2 Membrane trafficking Autophagy Lysosomal damage Lysosome Ap-3 Pi4k2a Atg9a Pi4p 
ProteomicsAP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic methods, including ‘Dynamic Organellar Maps’, to find proteins whose su...
ORGANISM(S): Homo sapiens (Human) 
2018-09-27 | PXD010103 | Pride
Human cells Autophagy Dynamic organellar maps Ap-4 Vesicles 
ProteomicsGFP-Trap ARFIP2 - ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair
Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving ER-lysosome membrane contact sites, phosphatidylinositol 4-kinase-2a (PI4K2A), phosphatidylinositol-4 phosphate (PI4P) and oxysterol-binding protein-related proteins (ORPs) li...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD056398 | Pride
Arfip2 Membrane trafficking Autophagy Lysosomal damage Lysosome Ap-3 Pi4k2a Atg9a Pi4p 
UnknownAP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Not available
S-EPMC6160451 | biostudies-literature
UnknownSEC31a-ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation.
Not available
S-EPMC11600210 | biostudies-literature
UnknownTepsin binds LC3B to promote ATG9A trafficking and delivery.
Not available
S-EPMC11064669 | biostudies-literature
UnknownATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair.
Not available
S-EPMC7617826 | biostudies-literature
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