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TranscriptomicsMicroarray analysis of gene expression in ATM-deficient MEFs
The expression of interferon-related genes was more enhanced in irradiated ATM-deficient mouse embryonic fibroblasts (MEFs) than in irradiated ATM wild-type MEFs. Nonirradiated-ATM-WT vs Irradiated-ATM-WT vs Nonirradaited-ATM-KO vs IrradiatedATM-KO
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-23116 | biostudies-arrayexpress
ProteomicsThe ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5
Ataxia telangiectasia mutated (ATM) is a protein that belongs to the family of phosphatidylinositol 3-kinase (PI3K)-like serine/threonine kinases. Initially identified as a nuclear protein essential for the DNA damage response (DDR) in mitotic cells, it serves as repair coordinator for DNA double-st...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-29 | PXD058394 | Pride
Taxol Sodium arsenite Coimmunoprecipitation Differential ultracentrifugation Label-free mass spectrometry Chloroquine Immobilized metal affinity chromatography Phosphoscan 
ProteomicsPhosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response
Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase Smad ubiquitin regulatory factor 2 (SMURF2) plays a critical tumor suppressing role via i...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-10-26 | PXD021420 | Pride
Smurf2 Atm Phosphorylation Dna damage response 
GenomicsPhosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids
Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids
PRJNA963212 | ENA
ProteomicsATM-knockout on total and phosphorylation proteomes of cortical brain organoids
ATM (ataxia telangiectasia mutated) kinase is crucial to a wide range of human developmental disorders and adult/pediatric malignancies. Its mutations are causally tied to ataxia telangiectasia, a multi-systemic congenital disorder mainly affecting brain and blood systems. We generated 4 separate ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD041699 | Pride
Phosphorylation proteome  proteome  atm kinase  cortical brain organoids 
ProteomicsTargeted mass spectrometry enables quantification of novel pharmacodynamic biomarkers of ATM kinase inhibitors
ATM is a serine/threonine protein kinase that is responsible for initiation of DNA repair of double-stranded breaks and is a therapeutic target in cancer. A lack of analytically robust and multiplexed assays has hampered mechanistic studies of action and determination of optimal, robust pharmacodyna...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD026103 | Pride
Human Lymphoblast Atm Phosphorylation 
TranscriptomicsEZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia
The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency. We previously found that nuclear accumulation of histone deacetylase-4, HDAC4, contributes to this degeneration; we now report that increased histone H3K27 trimethylation (H3K27me3) ...
ORGANISM(S): Mus musculus 
2013-10-25 | E-GEOD-50951 | biostudies-arrayexpress
ProteomicsROS-activated ATM-dependent phospho-signaling
ATM (ataxia-telangiectasia mutated) protein plays a central role in phosphorylating a network of proteins in response to DNA double strand breaks. These phosphorylated proteins function in signalling pathways designed to maintain the stability of the genome and minimize the risk of disease by contro...
ORGANISM(S): Homo sapiens (Human) 
2016-01-04 | PXD002850 | Pride
Reactive oxygen species Atm Fibroblast Phosphoproteomics 
ProteomicsATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
Mutations in the ATM tumor suppressor gene confer cellular hypersensitivity to various DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms towards such drugs, we performed genome-wide CRISPR-Cas9 loss-of-function screens in cells treated with the DNA topoisomerase I poison...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011108 | Pride
Atm Dna damage response 
TranscriptomicsPhosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids
53BP1 is a well-established DNA damage repair factor that has recently been shown to regulate gene expression and critically influence tumor suppression and neural development. For gene regulation, how 53BP1 is regulated remains unclear. Here, we showed that 53BP1-serine 25 phosphorylation by ATM is...
ORGANISM(S): Homo sapiens 
2024-08-11 | GSE231321 | GEO
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