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UnknownStructure of V-ATPase from the mammalian brain.
Not available
S-EPMC7324285 | biostudies-literature
UnknownATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation.
Not available
S-EPMC4894975 | biostudies-literature
UnknownSilencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion.
Not available
S-EPMC7927931 | biostudies-literature
ProteomicsImmunoprecipitation/Pull-down of ATP6AP1-FLAG in HEK293 WT cells treated with and without a mitochondrial translation inhibitor
Dataset: HEK293 WT cells were transfected with ATP6AP1-FLAG expression vector for 96h, with or without the presence of 15uM actinonin, a mitochondrial translation inhibitor. Immunoprecipitation was performed using FLAG antibody and Protein-G Sepharose, and the samples were analysed with label-free w...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD057148 | Pride
Atp6ap1/ac45 Crispr/cas9 Mitochondrial translation Organellar cross-talk V-atpase Proteostasis Mitochondrial disease Retrograde signalling 
TranscriptomicsTranscription profiling of melanized domamine neurons isolated from male and female patients with Parkinson disease to investigate gender differences
We used 500 melanized dopamine neurons isolated from post-mortem human substantia nigra pars compacta of each sample with laser capture microdissection. Total RNA was extracted with Arcturus PicoPure RNA extraction kit and amplified two times with Arcturus RiboAmp RNA amplification kit. the samples ...
ORGANISM(S): Homo sapiens 
2008-01-19 | E-MEXP-1416 | biostudies-arrayexpress
TranscriptomicsDevelopmental exposure to valproic acid alters the expression of microRNAs involved in neurodevelopment in zebrafish
Congenital malformations are a prevalent cause of infant mortality in the United States and their induction has been linked to a variety of factors, including exposure to teratogens. However, the molecular mechanisms of teratogenicity are not fully understood. MicroRNAs are an important group of sma...
ORGANISM(S): Danio rerio 
2013-06-19 | E-GEOD-48054 | biostudies-arrayexpress
TranscriptomicsGenetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent
The degree to which the level of genetic variation for gene expression is shared across multiple tissues has important implications for research investigating the role of expression on the aetiology of complex human traits and diseases. In the last few years, a number of studies have been published ...
ORGANISM(S): Homo sapiens 
2011-10-28 | E-GEOD-33321 | biostudies-arrayexpress
TranscriptomicsResponse of A549 cells treated with Aspergillus fumigatus [WT-CF_vs_WT-GC]
Response of A549 cells treated with Aspergillus fumigatus germinating conidia (WT-GC) or culture filtrate (WT-CF) for 8h Aspergillus fumigatus is the most commonly encountered mold pathogen of humans, predominantly infecting the respiratory system. Colonization and penetration of the lung alveolar e...
ORGANISM(S): Homo sapiens 
2010-10-29 | E-GEOD-24983 | biostudies-arrayexpress
TranscriptomicsOmic Personality: The Longitudinal Consistency of Transcriptional, Epigenetic and Clinical Profiles [DNA Methylation]
Background: Personalized medicine is predicated on the notion that individual biochemical and genomic profiles are relatively constant in times of good health and to some extent predictive of disease or therapeutic response. We report a pilot study quantifying gene expression and methylation prof...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-67490 | biostudies-arrayexpress
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