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TranscriptomicsThe investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell cycle progression in mouse bladder cancer cells in vitro and in vivo
PURPOSE: Despite over 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluate the role of Aurora A, identified as an upregulated candidate molecule in bladder cancer, in regulating bladde...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-42089 | biostudies-arrayexpress
ModelsAurora Kinase A in Neuroblastoma
Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
7916 | Cell Collective
ProteomicsAurora-A interactome in MV4-11 cells
To determine interactors of Aurora-A, HA tagged Aurora-A was immunoprecipitated from MV4-11 cells stably expressing HA tagged Aurora-A wild type and compared to MV4-11 cells expressing empty vector.
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD019684 | Pride
Aurora-a Mv4-11 
ProteomicsAurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics.
Precise regulation of kinetochore-microtubules is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote microtubule turnover. A critical target of Aurora B is the N-terminal “tail” domain of Hec1/NDC80, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-28 | PXD006892 | Pride
Human aurora a kinase hec1 
TranscriptomicsThe novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models
we report characterized the preclinical activity of a new member of this class, the ST1926-derivative ST5589, in lymphomas GEP analysis of 2 lymphoma cell lines with and without treatment
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-66455 | biostudies-arrayexpress
Proteomicspre-mRNA splicing is regulated by an Aurora-A-mediated phopsho-signaling network
In this study, we identified many new potential interactors of the Aurora-A kinase using a proteomic approach. A significant portion of Aurora-A interaction network is composed of proteins involved in pre-mRNA splicing, implying that Aurora-A signaling extends beyond its canonical function. Aurora-A...
ORGANISM(S): Homo sapiens (Human) 
2024-12-11 | PXD021093 | Pride
Aurora kinase Lc-ms/ms 
Proteomics293T Flag-Aurora-A Co-IP LC-MSMS
To explore the potential targets of Aurora-A in glycolytic regulation
ORGANISM(S): Homo sapiens (Human) 
2019-11-21 | PXD016110 | Pride
Human Lc-msms 293t Flag-aurora-a co-ip 
ProteomicsProteomics analysis with the Aurora-A PROTAC, JB170
The mitotic kinase Aurora-A is essential for cell cycle progression and considered a priority cancer target. Dozens of ongoing clinical trials are testing the anti-cancer potential of Aurora-A kinase inhibitors. While the catalytic activity of Aurora-A is essential for its function during mitosis, a...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD019585 | Pride
Proteomics analysis with the aurora-a protac Jb170 
TranscriptomicsAurora kinase A is upregulated in cutaneous T-cell lymphoma and represents a potential therapeutic target
Cutaneous T-cell lymphomas form a heterogeneous group of non-Hodgkin lymphomas characterized by only poor prognosis in advanced stage. Despite significant progress made in the identification of novel genes and pathways involved in the pathogenesis of cutaneous lymphoma, the therapeutic value of thes...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-59307 | biostudies-arrayexpress
ProteomicsProteomics analysis with the Aurora-A PROTAC, JB170
To determine specificity of Aurora-A PROTAC (JB170), MV4-11 cells were labeled with medium containing different stable isotopes (SILAC), treated them with JB170 or Alisertib and subsequently compared their protein content to untreated cells by quantitative mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD017342 | Pride
Aurora-a Protac Mv4-11 Degronimid Jb170 
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