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ProteomicsDisruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Kinase inhibitors (KIs) used in cancer therapeutics are associated with various side effects. One of the most significant adverse events that lead to discontinuation or modification of treatment is nephrotoxicity. We have identified BCR-ABL1 inhibitor dasatinib as a potential glomerular nephrotoxin ...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-29 | PXD011761 | Pride
Podocyte  kidney  dasatinib  bcr-abl  nephrotoxicity  cytoskeleton  actin  biophysics 
ProteomicsNebulette reinforces podocyte structural integrity by linking actin and vimentin filaments
One of the key aspects of the specialized podocyte morphology is the segregation and organization of distinct cytoskeletal filaments into different subcellular components, for which the exact mechanisms remain poorly understood. By screening the time-dependent proteomic changes within the rat puromy...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-15 | PXD016629 | Pride
Podocytes F-actin Nebulette Nephropathy 
ProteomicsIntegrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury
COVID-19 has been a significant public health concern for the last four years; however, not much is known about the mechanisms that lead to severe COVID-19. In this multicenter study, we combine quantitative urinary proteomics and machine learning to predict severe outcomes in hospitalized COVID-19 ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD051205 | Pride
Multiomics Tmt-16machine learning Kidney organoids Covid-19 Urine proteomics 
ProteomicsProteomic cellular signatures of kinase inhibitor-induced cardiotoxicity
Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is an integral part of the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. A key aim of DToxS is to generate both proteomic and transcriptomic signatures that cab predict adv...
ORGANISM(S): Homo sapiens (Human) 
2021-10-18 | PXD014791 | Pride
Cardiotoxicity Drug Signature Proteomics Mass spectrometry Kinase inhibitor 
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