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TranscriptomicsGene expression in Bach2-deficient and wildtype CD4 single-positive thymocytes from mixed chimeric animals
The role of FoxP3+ regulatory T (Treg) cells in the maintenance of immunological tolerance is well established. Recently, genome-wide association studies (GWAS) in humans have associated polymorphisms within the BACH2 locus encoding the transcription factor BTB and CNC homology 1, basic leucine zipp...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-42598 | biostudies-arrayexpress
TranscriptomicsTranscription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.
Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bac...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-54050 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of crypt samples isolated from the small intestine of Bach2 KO and control mice
Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. Here, we found that Bach2 deficiency promotes the intestinal epithelial cell proliferation during homeostasis and facilitates the crypt regeneration after irradiation, resulting in a reduction of ...
ORGANISM(S): Mus musculus 
2021-01-12 | E-MTAB-9865 | biostudies-arrayexpress
GenomicsBach2 represses effector programmes to stabilize Treg-mediated immune homeostasis
Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunctio...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-45975 | biostudies-arrayexpress
TranscriptomicsRole and function of Bach2 in BCR-ABL1 driven pre-B ALL
In order to investigate the function of Bach2 in pre-B ALL, we isolated bone marrow cells from wildtype and Bach2 knockout mice of C57Bl6 background and transformed them with BCR-ABL1. We compared the gene expression profiles of Bach2 wildtype and knockout pre-B ALL cells, both with and without ima...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-30883 | biostudies-arrayexpress
TranscriptomicsEffect of Bach2 overexpression in BCL6+/+ and -/- BCR-ABL1 transformed pre-B cells
The aim was to investigate how BCL6 genotype affects Bach2 dependent gene expression changes. We compared gene expression profiles of BCL6+/+ and BCL6-/- BCR-ABL1 transformed pre-B cells after inducible overexpression of Bach2.
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-41042 | biostudies-arrayexpress
ProteomicsSuper-killer CTLs are generated by single gene deletion of Bach2
Bach2 codes for a transcriptional regulator exerting major influences on T cell mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8+ T cells showed increased proliferative and cytolytic capacity in the absence of BACH2. Before activation, BACH2-deficient CD8+ T c...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-02 | PXD036457 | Pride
T cell Proteomics Bach2 Cd8 Ctl Tmt 
TranscriptomicsCUT&RUN profiling of BACH2, NRF2, and NFE2 in human primary CD34⁺ hematopoietic stem/progenitor cells and day-8 erythroid cells under wild-type and BACH2 knockdown conditions
CUT&RUN was performed to profile BACH2, NRF2, and NFE2 occupancy in human primary CD34⁺ hematopoietic stem and progenitor cells (day 0) and erythroid cells differentiated from CD34⁺ HSPCs (day 8). Experiments were conducted under wild-type, scrambled control, and BACH2 shRNA knockdown conditions to ...
ORGANISM(S): Homo sapiens 
2026-09-02 | E-MTAB-16108 | biostudies-arrayexpress
TranscriptomicsThe transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program
Mature lymphoid cells express the transcriptional repressor Bach2, which imposes regulation on humoral and cellular immunity. Here we found critical roles for Bach2 in the development of cells of the B lineage, commencing from the common lymphoid progenitor (CLP) stage, with Bach1 as an auxiliary. O...
ORGANISM(S): Mus musculus 
2014-10-26 | E-GEOD-61409 | biostudies-arrayexpress
GenomicsCooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation
The transcriptional repressors BCL6 and BACH2 are crucial regulators of germinal center (GC) B-cell fate, and are known to interact and repress transcription of PRDM1, a key driver of plasma cell differentiation. How these factors cooperate is not fully understood. Herein we show that while GC forma...
ORGANISM(S): Homo sapiens 
2013-11-17 | E-GEOD-47784 | biostudies-arrayexpress
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