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ProteomicsEnhancing Cysteine Chemoproteomic Coverage Through Systematic Assessment of Click Chemistry Product Fragmentation - 2
Higher-energy C-trap dissociation (HCD) of triazole-and biotin-modified peptides affords several characteristic fragment ions, including previously reported and newly identified species. Using the open and mass offset search strategies, we conduct an in-depth analysis of the relative intensities and...
ORGANISM(S): Homo sapiens (Human) 
2022-07-22 | PXD030737 | Pride
Fragmentation Chemoproteomics Diagnostic ions Biotinylation 
ProteomicsSP3-enabled rapid and high coverage chemoproteomic identification of redox-sensitive cysteines
Cysteine residues undergo various oxidative modifications, acting as key sensors of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Given that ROS and RNS have known roles in many pathophysiological processes, numerous proteome-wide strategies to profile cysteine oxidation state h...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD029500 | Pride
Chmoproteomics Cysteines Quantitation Mass spectrometry Redox T cells Isotopic 
ProteomicsSP3-enabled rapid and high coverage chemoproteomic identification of redox-sensitive cysteines
Cysteine residues undergo various oxidative modifications, acting as key sensors of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Given that ROS and RNS have known roles in many pathophysiological processes, numerous proteome-wide strategies to profile cysteine oxidation state h...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD031647 | Pride
Cysteine Chemoproteomics Redox 
ProteomicsMulti-omic stratification of the missense variant cysteinome
Cancer genomes are rife with genetic variants; one key outcome of this variation is gain-of-cysteine, which is the most frequently acquired amino acid due to missense variants in COSMIC. Acquired cysteines are also both driver mutations and sites targeted by precision therapies. However, despite the...
ORGANISM(S): Homo sapiens (Human) 
2024-10-03 | PXD043879 | Pride
Cancer Proteogenomics Drug Proteomics Mass spectrometry Chemical proteomics Biology Lc-ms/ms Mutation 
ProteomicsProximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome
Proteinaceous cysteines function as essential sensors of cellular redox state. Consequently, defining the cysteine redoxome is a key challenge for functional proteomic studies. While proteome-wide inventories of cysteine oxidation state are readily achieved using established, widely adopted proteomi...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-08-10 | PXD039626 | Pride
Cysteine Chemoproteomics Redox sensitive Proximity labeling 
ProteomicsA high-throughput screening approach identified a selective pro-caspase-10 probe that can inhibit its activity
Caspases are cysteine proteases that play a critical role in inflammation and apoptosis. Caspases have a functional role in either the intrinsic apoptotic pathway as initiators of apoptosis or in the extrinsic apoptotic pathway as executioners of apoptosis. Caspase-10 has been speculated to play a p...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD053315 | Pride
Caspase-10 Hts Biotin azide 
ProteomicsCIAA: Integrated Proteomics and Structural Modeling for Understanding Cysteine Reactivity with Iodoacetamide Alkyne
This study utilizes cysteine chemoproteomics paired with a high-throughput structure-guided in silico approach towards assessing structural motifs of cysteines that are highly reactive towards iodoacetamide alkyne (IAA).
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD056064 | Pride
Reactivity Cysteine Chemoproteomics Isotop-abpp 
ProteomicsCholesterol binding to VCAM-1 promotes vascular inflammation
Hypercholesterolemia has long been implicated in endothelial cell (EC) dysfunction, but the mechanisms by which excess cholesterol causes vascular pathology are incompletely understood. Here we used a cholesterol-mimetic probe to map cholesterol-protein interactions in primary human ECs and discover...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000099325 | MassIVE
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