Sort   by:  
 Page size 
MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
MetabolomicsProteolytic-Resistant Self-Assembling Peptide Nanofibers Combat Specific Bacterial Infections via Trap-and-Kill

The rise in global antibiotic resistance highlights the urgent need for effective antimicrobial agents. Antimicrobial peptides (AMPs) offer a potential solution to combat bacterial resistance. However, key challenges remain in addressing the limitations of current peptide drugs and biomaterials, ...

2025-06-13 | MTBLS12424 | MetaboLights
ProteomicsClpP protease modulates bacterial growth, stress response and bacterial virulence in Brucella abortus
Intracellular proteolysis via ATP-dependent proteases is a conserved biological process. The ATP-dependent Clp protease is made up of peptidase ClpP and ATP-dependent chaperones and plays an important role in the proteolysis process. In several pathogenic bacteria, the Clp protease is implicated in ...
ORGANISM(S): Brucella abortus (strain 2308) 
2023-10-24 | PXD034842 | Pride
Virulence Itraq analysis Brucella Clpp protease 
TranscriptomicsVibrio cholerae lon protease mutant microarray analysis
Lon protease is known to regulate various transcriptional regulators in other bacterial organisms. To understand whether lon protease is involved in transcriptional changes in Vibrio cholerae, wholel-genome level transcriptional profiling was performed using custom microarrays. Transcriptomes of lon...
ORGANISM(S): Vibrio cholerae 
2016-01-06 | E-GEOD-73023 | biostudies-arrayexpress
TranscriptomicslonB mutant
The bacterial Lon protease participates in a variety of biological processes. In Pseudomonas syringae, mutation of lon is known to activate hrpL and a few hrpL-regulated genes in the rich medium. The elevated expression of hrpL and hrpL-regulated genes results from of increased stability of HrpR, th...
ORGANISM(S): Pseudomonas syringae pv. tomato str. DC3000 
2007-10-14 | E-GEOD-6121 | biostudies-arrayexpress
ProteomicsPeptidomic analysis of bacterial protease activity in acute wound fluids
The clinical assessment of wound infection and related complications is challenging and the development of objective methods to measure wound status and predict healing outcomes is therefore essential. As bacterial protease activities play important roles in infection, analysis of changes in the wou...
ORGANISM(S): Homo sapiens (Human) 
2024-03-07 | PXD037047 | Pride
Human Lc-msms Wound fluids proteases Peptidome 
ProteomicsRhomboid mediates membrane protein quality control as an intramembrane protease and adaptor of AAA protease.
Magnesium homeostasis is essential for life and depends on magnesium transporters whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom but their functions are largely elusive. Using proteomics we find that Bacillus subtili...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-01-09 | PXD014578 | Pride
Transporter Er associated degradation Intramembrane protease Manganese Tripletof 5600 Magnesium Bacillus subtilis Lipid membrane Gelc-ms/ms Rhomboid protease Proteostasis Zinc 
ProteomicsPeptidomic analysis of endogenous and bacterial protease activity in human plasma
The clinical assessment of wound infection and related complications is challenging and the development of objective methods to measure wound status and predict healing outcomes is therefore essential. As endogenous and bacterial protease activities play important roles in healing and infection, ana...
ORGANISM(S): Homo sapiens (Human) 
2024-03-07 | PXD037245 | Pride
Human Lc-msms Plasma Proteases Peptidome 
TranscriptomicsReaeration timecourse from a defined hypoxia model
Reaeration timecourse from a defined hypoxia model in Mycobacterium tuberculosis. The mechanism by which mycobacteria return to a replicating state upon re-exposure to favorable conditions is not well understood. In this study, we utilized reaeration from a defined hypoxia model to characterize the...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-28 | E-GEOD-21590 | biostudies-arrayexpress
TranscriptomicsRegulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
Alterations in the gastrointestinal microbiota have been implicated in obesity in mice and humans, but the conserved microbial functions that influence host energy metabolism and adiposity have not been determined. Here we show that bacterial bile salt hydrolase (BSH) controls a microbe-host dialogu...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-46952 | biostudies-arrayexpress
Sort   by:  
 Page size