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ProteomicsHuman breast cancer biopsies of patients treated or not with the combination of palbociclib and fulvestrant
Metastatic HR+ HER2- breast cancer is an intractable disease that resists to the first-line treatment based on the combination of CDK4/6 inhibitor and hormone therapy (HT). To identify targets that further increase palbociclib-HT efficacy, we utilized biopsies from cancer patients who showed recurre...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053296 | Pride
Human Lc-msms Biopsies Lcm 
ProteomicsWobble tRNA modification dependent protein aggregates modification
We want to assess the features of proteins whose aggregation depends on defects in traslation by the loss of the mcm5s2 modification on the urifdine in position 34 of some tRNAs.
ORGANISM(S): Homo sapiens (Human) 
2021-02-24 | PXD019590 | Pride
Trna modification Aggregates Elongator Cancer 
ProteomicsBiomarkers discovery for Colorectal cancer liver metastasis
Identification of early diagnostic and prognostic biomarkers measurable in liquid biopsies remains a major challenge in oncology today. OMICs technologies cannot be applied on clinically precious human material as this is required in its integrity for routine pathology investigation. Hence all OMIC...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005709 | Pride
Colon cancer liver metastasis Proteomic Human 
ProteomicsBiomarkers discovery for Colorectal cancer
Identification of early diagnostic and prognostic biomarkers measurable in liquid biopsies remains a major challenge in oncology today. OMICs technologies cannot be applied on clinically precious human material as this is required in its integrity for routine pathology investigation. Hence all OMIC...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005693 | Pride
Colon cancer Proteomic Human 
ProteomicsProtein (elafin) cleavage by the main Lactobacillus spp encountered in the female gynecological tract
Mass spectrometry analyses for determining whether 13C615N2-labeled lysines contained in the elafin (innate peptide highly expressed in lower female genital tract and down-regulated in case of HPV infection) were found in the amino acid sequence of some proteins of Lactobacilli, supporting the funda...
ORGANISM(S): Lactobacillus 
2022-04-04 | PXD022113 | Pride
Elafin Lactobacillus 
ProteomicsLC-M/MS Protein aggregation isolation is murine melanoma lines after OSGEP depletion
The immune response in cancer, particularly in melanoma, is often hindered by tumour-induced immune evasion strategies, but the precise mechanisms for this remains unclear. Here, we reveal how the tRNA modification threonine-6-adenosine (t6A), mediated by O-sialoglycoprotein endopeptidase (OSGEP), m...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD059835 | Pride
Trna modification Melanoma Protein misfolding 
TranscriptomicsBT549 cells depleted of ELP3 compared to control
Understand the proteome dependent on the mcm5s2 U34 tRNA modification in breast cancer
ORGANISM(S): Homo sapiens 
2020-06-20 | E-MTAB-9206 | biostudies-arrayexpress
ProteomicsDiscovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohn’s patients: a proteomics-based study
Objective: A subset of Crohn’s disease (CD) patients experiences long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients. Design: New biomarkers of relapse were searched in the baseline serum of CD patients stopping infliximab when they were under combined t...
ORGANISM(S): Homo Sapiens 
2020-11-02 | PXD019434 | panorama
ProteomicsExternal validation of serum biomarkers predicting short-term and mid/long-term relapse in Crohn’s disease patients stopping infliximab
Background and aims: In Crohn’s disease (CD) patients on combination therapy (infliximab and immunosuppressant) and stopping infliximab (STORI cohort), the risk of short-term (<6 months) and mid/long-term relapse (>6 months) was associated with specific blood protein profiles. Our aim was to test th...
ORGANISM(S): Homo Sapiens 
PXD051233 | panorama
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