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ProteomicsQuantitative LC-MS/MS Proteomics of paediatric human liver microsomes (set 2)
We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in 24 human liver microsomal samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based pharmacokinetic models to ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020939 | Pride
Human Quantitative proteomics Paediatric livers Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS Proteomics of paediatric biliary atresia human liver microsomes
We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in 25 human liver microsomal samples, taken from patients with biliary atresia. Nearly 3500 proteins were identified and quantified. These data can be used in physiolog...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020974 | Pride
Human Quantitative proteomics Biliary atresia Paediatric livers Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS Proteomics of human small intestine
The objective was to determine the expression of a wide range proteins pertinent to metabolism and disposition of chemicals and nutrients in the intestinal epithelium. Ileum and jejunum biopsy specimens were obtained from 16 patients undergoing gastrointestinal elective surgery. Mucosal fractions we...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020987 | Pride
Human Jejunum Small intestine Gut Quantitative proteomics Ileum Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS Proteomics of human liver microsomes
We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in 20 human liver microsomal samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based pharmacokinetic models to ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD020910 | Pride
Human Adult livers Quantitative proteomics Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS Proteomics of paediatric human liver microsomes
We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in 20 human liver microsomal samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based pharmacokinetic models to ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020844 | Pride
Human Quantitative proteomics Paediatric livers Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS proteomics of human kidney microsomes
The aim of this study was to quantify enzymes and transporters in 20 human kidney cortex fractions. Using targeted accurate mass retention time (AMRT) and global proteomic approaches, 6 UGTs, 3 CYPs, 22 transporters, 1 adhesion and 1 plasma membrane marker were quantified; Eight of these proteins we...
ORGANISM(S): Homo sapiens (Human) 
2021-08-30 | PXD020996 | Pride
Human Microsomes Kidney Quantitative proteomics Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS Proteomics of human skin and LabSkin model
We report for the first time label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in six human skin explants and a 3D living skin equivalent model from LabSkin. More than 2000 proteins were identified and quantified from total cell...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD020742 | Pride
Human Skin Labskin Lc-ms/ms 
ProteomicsGASP and FASP are complementary for LC-MS/MS proteomic analysis of drug-metabolising enzymes and transporters in pig liver
Sample preparation is a critical step in the proteomic workflow. Numerous different approaches are used, tailored to the type of sample, the aims of the experiment, analytical method, and to an extent, user preference. This has resulted in large variation in reported protein abundances. In this stud...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-11-12 | PXD011324 | Pride
Gasp Sample preparation Fasp Pig liver Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS Proteomics of human liver microsomes (healthy controls and normal-tumour from cancer patients)
We report quantification of proteins in human liver microsomal samples from 15 healthy volunteers and 18 patients with cancer in the liver (mainly, colorectal cancer liver metastasis). These data can be used in physiologically based pharmacokinetic models to predict appropriate drug doses in patient...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038776 | Pride
Human Healthy controls and normal-tumour livers from cancer patients Quantitative proteomics Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS Proteomics of human brain microvessels
We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases, nucleases and tight junction proteins in 22 human brain microvessel samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021018 | Pride
Human Brains Quantitative proteomics Lc-ms/ms 
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