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ProteomicsThe β2-subunit of voltage-gated calcium channels inhibits cardiomyocyte hypertrophy through a channel-independent mechanism.
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cav1 pore-forming subunit and the accessory subunits Cav, Cav2 and Cav. Cav is a cytosolic soluble protein that regulates channel trafficking and activity, but it also exerts...
ORGANISM(S): Rattus norvegicus (Rat) Rattus 
2021-09-09 | PXD016483 | Pride
L-type voltage-gated calcium channels  cav-subunit  cardiac hypertrophy  calpain  cardiomyocytes  calpastatin 
ProteomicsBlood contamination in CSF and its impact on quantitative analysis of alpha-synuclein
Analysis of cerebrospinal fluid (CSF) is important for diagnosis of neurological diseases. Specific proteins, which are released from the CNS can be quantitatively monitored. Especially, in the field of neurodegenerative diseases abnormal protein abundance is an important biomarker. However, the qua...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD014515 | Pride
Alpha-synuclein Elisa Urine strip Cerebrospinal fluid Bottom-up mass spectrometry Blood contamination Quantification 
ProteomicsSuper-SILAC reveals intricate crosstalk between lipopolysaccharide, phospholipid and fatty acid metabolism in Escherichia coli
The only membrane-anchored and essential ATP-dependent protease in Escherichia coli is FtsH. It controls the intracellular concentration of the deacetylase LpxC, which catalyses the first committed step in lipopolysaccharide biosynthesis. LpxC stability is strictly regulated in a growth rate-depende...
ORGANISM(S): Escherichia coli 
2019-11-12 | PXD006195 | Pride
Lipopolysaccharide Lc-ms/ms Escherichia coli Ftsh Lpxc Proteolysis Super-silac Quantitative proteomics 
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine diseases of the central nervous system through analyzing its components. These include the analysis of metabolites, cells as well as proteins. For identifying new suitable diagnostic protein bi...
ORGANISM(S): Homo sapiens (Human) 
2018-09-17 | PXD010705 | Pride
Cerebrospinal fluid Dia Proteomics Data-independent acquisition mass spectrometry Csf Spectral library 
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine diseases of the central nervous system through analyzing its components. These include the analysis of metabolites, cells as well as proteins. For identifying new suitable diagnostic protein bi...
ORGANISM(S): Homo sapiens (Human) 
2018-09-17 | PXD010708 | Pride
Cerebrospinal fluid Dia Proteomics Data-independent acquisition mass spectrometry Csf Spectral library 
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine diseases of the central nervous system through analyzing its components. These include the analysis of metabolites, cells as well as proteins. For identifying new suitable diagnostic protein bi...
ORGANISM(S): Homo sapiens (Human) 
2018-09-17 | PXD010698 | Pride
Cerebrospinal fluid Dia Proteomics Data-independent acquisition mass spectrometry Csf Spectral library 
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine neurodegenerative diseases in order to identify suitable diagnostic biomarkers. In the field of neuroproteomics the most popular mass spectrometry-based strategy for biomarker discovery studies...
ORGANISM(S): Homo sapiens (Human) 
2018-09-17 | PXD009624 | Pride
Cerebrospinal fluid Lc-ms Spectral library Data-independent acquisition 
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine diseases of the central nervous system through analyzing its components. These include the analysis of metabolites, cells as well as proteins. For identifying new suitable diagnostic protein bi...
ORGANISM(S): Homo sapiens (Human) 
2018-09-17 | PXD010690 | Pride
Cerebrospinal fluid Dia Proteomics Data-independent acquisition mass spectrometry Csf Spectral library 
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine neurodegenerative diseases in order to identify suitable diagnostic biomarkers. In the field of neuroproteomics the most popular mass spectrometry-based strategy for biomarker discovery studies...
ORGANISM(S): Homo sapiens (Human) 
2019-02-14 | PXD009623 | Pride
Cerebrospinal fluid Lc-ms Spectral library Data-independent acquisition 
ProteomicsInteractome of the -subunit of L-type voltage-gated calcium channels in adult cardiomyocytes
In cardiomyocytes, Ca2+ influx through L-type voltage-gated calcium channels (LTCCs) following membrane depolarization regulates crucial Ca2+-dependent processes including duration and amplitude of the action potentials and excitation-contraction coupling. LTCCs are heteromultimeric proteins compose...
ORGANISM(S): Rattus rattus (Black rat) 
2021-12-14 | PXD021375 | Pride
Dstorm Ca2+ influx Proteomics L-type voltage-gated calcium channels (ltccs) Nano-environments of cav2 Pull-down Cardiomyocytes 
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