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TranscriptomicsChIP-on-chip of BCL6
Identification BCL6 target genes in primary germinal center cells and DLBCL cell lines by ChIP-on-chip Three replicates in each type of cells
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-15179 | biostudies-arrayexpress
ProteomicsModification sites and interaction proteins of BCL6
For MS of BCL6 modification sites and interaction proteins, the gel band of BCL6 was excised and digested with trypsin. Immunocomplexes were identified on Thermo Scientific Orbitrap Fusion Lumos. The data for this project include raw data.
ORGANISM(S): Homo sapiens (Human) 
2025-11-29 | PXD062920 | Pride
TranscriptomicsDNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas
Elevated DNA methylation in the first intronic region of the BCL6 locus in B cell lymphomas enforces transcription of the BCL6 gene Promoter tiling arrays were used to investigate the distribution of DNA methylation near the promoter region of BCL6 locus Comparison of DNA methylation at promoter reg...
ORGANISM(S): Homo sapiens 
2010-08-20 | E-GEOD-22884 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
ProteomicsSmall molecule-induced polymerization triggers degradation of BCL6
Most small-molecule protein degraders act as interface stabilizers ‘molecular glues’ between E3 ubiquitin ligases and target proteins to induce ternary complex formation and ubiquitin-dependent target protein degradation. Here we report polymerization as a novel mechanism for small molecule-induced ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD016185 | Pride
Polymerization Bcl6 Molecular glue Siah1 Ubiquitin Btb Dlbcl 
TranscriptomicsThe BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers
Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. RNAseq was performed in endogeno...
ORGANISM(S): Homo sapiens 
2014-09-14 | E-GEOD-58365 | biostudies-arrayexpress
ProteomicsImmediate adaption – Quantitative Proteomics of BCL6 silencing and EGFR TK inhibition
We aimed to identify the response mechanism to EGFR tyrosine kinase inhibition. A431 cells were transfected with mock siRNA or BCL6 siRNA. Cells were then treated with gefitinib. Harvesting was done at 0h, at 24h and at 48h. Two TMT10plex sets were organized as follows: TMT set1: mock 0h (3x, channe...
ORGANISM(S): Homo sapiens (Human) 
2020-12-09 | PXD016605 | Pride
Human Bcl6 sirna Tmt proteomics Lc-ms Time course Egfr inhibition Gefitinib A431 cells 
TranscriptomicsA Bcl6-Smrt/Ncor repression program controls atherosclerosis
This SuperSeries is composed of the following subset Series: GSE27001: Inhibition of Bcl6-SMRT/NCoR interactions by an inhibitory peptide affects inflammatory pathways GSE27033: Genome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-27060 | biostudies-arrayexpress
GenomicsBCL6 is required for the initiation and maintenance of chronic myeloid leukemia
We identified the BCL6 protooncogene as a critical downstream effector of FoxO3A in self-renewal signaling of CML-initiating cells. BCL6 represses Arf and p53 in CML cells and is required for leukemia stem cell maintenance, colony formation and initiation of leukemia in transplant recipients. Import...
ORGANISM(S): Homo sapiens 
2011-09-15 | E-GEOD-26085 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken Bcl6 deficient DT40 B cell line to investigate the targets of Bcl6 which is required for germinal center formation
The transcription factor Bcl6 is required for germinal center formation and deregulated expression of Bcl6 has been observed in lymphomas. To gain insight to the function of Bcl6 in terminal differentiation of B cells to plasma cells and to investigate the targets of Bcl6, we established a Bcl6 defi...
ORGANISM(S): Gallus gallus 
2010-02-17 | E-MEXP-2062 | biostudies-arrayexpress
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