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ProteomicsLiP-Quant, an automated chemoproteomic approach to identify drug targets in complex proteomes, p3
LiP-Quant MS sample preparation for target deconvolution
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD019902 | Pride
Small molecules Lc-ms Target deconvolution Lip-quant 
ProteomicsVCP D1 ATPase activation enhances both autophagic and proteasomal neurotoxic protein clearance
Autophagy upregulation enhances the clearance of various neurotoxic proteins and ameliorates their toxicities in disease models. Thus, autophagy activators may have therapeutic utility. Here, we have identified the essential protein VCP/p97 as a target of the autophagy-inducing molecule SMER28, prov...
ORGANISM(S): Escherichia coli 
2022-07-15 | PXD027750 | Pride
Beclin 1 Atpase Smer28 Autophagy Ubiquitin-proteasome system Limited proteolysis Lip-ms Neurodegeneration Vcp Protein quality control 
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