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ProteomicsLiP-Quant, an automated chemoproteomic approach to identify drug targets in complex proteomes, p3
LiP-Quant MS sample preparation for target deconvolution
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD019902 | Pride
Small molecules Lc-ms Target deconvolution Lip-quant 
ProteomicsLiP-Quant, an automated chemoproteomic approach to identify drug targets in complex proteomes
Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in developing optimized leads. We have developed a drug target deconvolution approach with an automated data analysis pipeline, based on limi...
ORGANISM(S): Homo sapiens (Human) Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) Saccharomyces cerevisiae (Baker's yeast) 
2020-09-09 | PXD015446 | Pride
Limited proteolysis Dia-ms Lip-ms Drug identification 
ProteomicsLiP-Quant, an automated chemoproteomic approach to identify drug targets in complex proteomes, p2
Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in developing optimized leads. We have developed a drug target deconvolution approach with an automated data analysis pipeline, based on limi...
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD018204 | Pride
Limited proteolysis Dia-ms Lip-ms Drug identification 
ProteomicsProteome-Wide Deconvolution of Drug Targets and Binding Sites by Lysine Reactivity Profiling
Recently, numerous efforts have been devoted to identifying drug targets and binding sites in complex proteomes, which is of great importance in modern drug discovery. In this study, we developed a robust lysine reactivity profiling method to systematically study drug-binding targets and binding sit...
ORGANISM(S): Homo Sapiens 
2023-09-28 | PXD045749 |
UnknownA machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.
Not available
S-EPMC7442650 | biostudies-literature
ProteomicsCatechol-O-Methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis and protein folding in schizophrenia
Dysregulation of dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol‑O‑methyltransferase (COMT), an enzyme critical for degrading dopamine (DA) in the dorsolateral prefrontal cor...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-28 | PXD075030 | Pride
Limited proteolysis Thermo-fisher ascend Rat Pc12 cells 
ProteomicsVCP D1 ATPase activation enhances both autophagic and proteasomal neurotoxic protein clearance
Autophagy upregulation enhances the clearance of various neurotoxic proteins and ameliorates their toxicities in disease models. Thus, autophagy activators may have therapeutic utility. Here, we have identified the essential protein VCP/p97 as a target of the autophagy-inducing molecule SMER28, prov...
ORGANISM(S): Escherichia coli 
2022-07-15 | PXD027750 | Pride
Beclin 1 Atpase Smer28 Autophagy Ubiquitin-proteasome system Limited proteolysis Lip-ms Neurodegeneration Vcp Protein quality control 
TranscriptomicsEffect of prostacyclin in ovarian carcinoma
CAFs, ascTAMs and M1- and TAM-like-MDMs were treated with 1 μM of the Prostacyclin analoga MRE and DMSO (as solvent control). The aim of this experiment is to see which effect MRE (Prostacyclinanaloga) has on RNA expression (activation of signaling pathways). Background: Prostacyclin receptor expres...
ORGANISM(S): Homo sapiens 
2022-12-16 | E-MTAB-12437 | biostudies-arrayexpress
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