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TranscriptomicsWoman skeletal muscle transcriptome with bed rest and countermeasures.
Microgravity has a dramatic impact on human physiology, illustrated in particular with skeletal muscle impairment. A thorough understanding of the mechanisms leading to loss of muscle mass and structural disorders is necessary for the definition of efficient clinical and spaceflight countermeasures....
ORGANISM(S): Homo sapiens 
2010-09-10 | E-GEOD-14798 | biostudies-arrayexpress
ProteomicsPlasma proteome profiling of healthy subjects undergoing bed rest reveals unload-dependent changes linked to muscle atrophy.Plasma proteome profiling of healthy subjects undergoing bed rest reveals unload-dependent changes linked to muscle atrophy.
Inactivity and unloading. induce skeletal muscle atrophy, loss of strength and detrimental metabolic effects. We used mass spectrometry-based proteomics to measure the abundance changes of proteins circulating in the blood plasma of young healthy subject undergoing ten days of continuous bed rest. S...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032969 | Pride
Bed rest Proteomics Plasma Skeletal muscle Cachexia Atrophy 
TranscriptomicsInsulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men
Rationale: Physical inactivity is a risk factor for insulin resistance. We examined the effect of nine days of bed rest on basal and insulin stimulated expression of genes potentially involved in insulin action by applying hypothesis-generating microarray in parallel with candidate gene real-time PC...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-24215 | biostudies-arrayexpress
ProteomicsAssessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition
Head-down bed rest (HDBR) is one of the models of the physiological effects of weightlessness used, among other things, to assess the effect of hypokinesia on the physiological systems of the human body and, first of all, on the cardiovascular system. The aim of the work was to study the effect of 2...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD053149 | Pride
Head-down bed rest Mass spectrometry Blood Retinol-binding protein Cardiovascular system 
ProteomicsAssessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition, including markers sST2, NT-proBNP and D-dimer
Head-down bed rest (HDBR) is one of the models of the physiological effects of weightlessness used, among other things, to assess the effect of hypokinesia on the physiological systems of the human body and, first of all, on the cardiovascular system. The aim of the work was to study the effect of 2...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD043604 | Pride
Head-down bed rest Mass spectrometry Nt-probnp D-dimer Sst2 
ProteomicsHuman (21d bed rest) Muscle LC-MSMS
Muscle atrophy is one of the main deleterious consequences of physical inactivity. Bed rest represents a unique model of physical inactivity and results in main changes in muscle metabolic function. However, our knowledge on the detrimental effects of bed rest still needs clarification. The aim of t...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD006882 | Pride
Human Lc-msms Countermeasures Inactivity Muscle Atrophy 
TranscriptomicsEffects of a nutritional supplement in older individuals subject to ten days of complete bed rest.
Older individuals subjected to complete bed rest for 10 days were randomized to a complete nutritional supplement with or without hydroxymethyl butyrate (HMB). Muscle biopsies from the vastus lateralis were obtained immediately prior and at the conclusion of the bed rest. RNA-sequencing was performe...
ORGANISM(S): Homo sapiens 
2019-11-01 | GSE130722 | GEO
GenomicsEffects of a nutritional supplement in older individuals subject to ten days of complete bed rest.
Effects of a nutritional supplement in older individuals subject to ten days of complete bed rest.
PRJNA541175 | ENA
TranscriptomicsChromatin immunoprecipitation of REST/NRSF
ENCODE ChIP-chip study using 8 diverse human cell lines; 4 of neural origin (NB69, KELLY, SHSY-5Y, U373) and 4 of non-neural origin (HeLa, HepG2, HEK293 and K562) and anti-REST/NRSF antibody (Santa Cruz Biotech; sc-25398 aka H290) to asses REST-genome interactions across 1% of the human genome used...
ORGANISM(S): Homo sapiens 
2009-03-31 | E-TABM-660 | biostudies-arrayexpress
TranscriptomicsGene expression in skeletal muscle in older individuals subject to ten days of complete bed rest.
Older individuals were subjected to complete bed rest for 10 days. Muscle biopsies from the vastus lateralis were obtained immediately prior and at the conclusion of the bed rest. RNA-sequencing was performed to determine the gene expression changes associated with bed rest. Marked decrease in the e...
ORGANISM(S): Homo sapiens 
2019-09-24 | GSE126865 | GEO
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