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ProteomicsAssociations between cellular energy and pediatric inflammatory bowel disease patient response to treatment
Crohn’s disease (CD) and ulcerative colitis are chronic inflammatory bowel diseases (IBD) of which the etiology and pathogenesis are not completely understood. In paediatric patients, the disease tends to be more severe and aggressive then in adults. Here, we perform a proteomic approach on ascendin...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD024229 | Pride
Inflammatory bowel disease Proteomics Pediatric 
ProteomicsHuman colon aspirate proteins analyzed by LC-MSMS
Colonic aspirates were collected at diagnostic colonoscopy from inflammatory bowel disease (IBD) and control, treatment-naive children. The colonic mucosal-luminal interface (MLI) proteomes were analyzed for 18 control and 42 IBD patients by liquid-chromatography mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2018-03-19 | PXD006383 | Pride
Human Lc-msms Colon aspirates 
ProteomicsAltered microbiota-host mutualism and bloom of Atopobium define severe pediatric Crohn's disease
Microbial dysbiosis has been identified in adult inflammatory bowel disease (IBD) patients. However, microbial composition and functional interplay between host genetics and microorganisms in early IBD onset remain poorly defined. Here, we identified and demonstrated the causal effect of Atopobium ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD000690 | Pride
Ibd Colon 
ProteomicsAscending colon biopsies from pediatric patients
We sought to identify proteins that enable differentiation between CD and UC in children with new onset IBD. Mucosal biopsies were obtained from children undergoing baseline diagnostic endoscopy prior to therapeutic interventions. Using a super-stable isotope labeling with amino acids in cell cultur...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD005086 | Pride
Colon Lcmsms 
TranscriptomicsGene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [Expression]
From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification of mRNA expression profiles (Affymetrix U133Pl...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-39582 | biostudies-arrayexpress
TranscriptomicsGene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [CGH]
From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification of mRNA expression profiles (Affymetrix U133Pl...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-40966 | biostudies-arrayexpress
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