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ProteomicsMurine kidney glomeruli phosphorylation
Isolated murine kidney glomeruli were lysed in buffer containing 8M urea, and proteins were reduced and alkylated. Proteins were digested with trypsin. After reverse-phase chomatrography, peptides were fractionated using strong cation exchange chromatography. Phosphopeptides were enriched using IMAC...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-09 | PXD000266 | Pride
Mouse Podocytes Kidney Glomerular epithelial cell Phosphoproteomics 
ProteomicsMouse kidney glomeruli. Control vs. podocin(R231Q/A268V)
Similar to human patients, mice with the compound heterozygous mutation podocin R231Q/A268V, develop a late onset FSGS. Here, we did a proteomics anaylsis of kidney glomeruli before the onset of disease (mice at 3 weeks of age). Analysis of the data reveals that there are no developmental changes in...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-15 | PXD018326 | Pride
Podocin Glomerulus Kidney Nphs2 
ProteomicsProteomic analysis of cisplatin exposure on the kidney cortex proteome and the effect of preconditioning
Acute kidney injury and nephrotoxicity are important clinical side effects of cisplatin. Thus, the mechanisms of this disease, and potential treatment options are important to understand in their entity. Here, we analyzed the proteome of cisplatin induced acute kidney injury in a mouse model. Functi...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-30 | PXD005525 | Pride
Caloric restriction Cisplatin Kidney 
ProteomicsDeep mapping of the mouse podocyte proteome
We analyzed the proteome of mouse FACS-sorted podocytes. We compared podocytes ("green cells") with non-podocyte ("red cells") cells of the glomerulus.
ORGANISM(S): Mus musculus (Mouse) 
2018-06-21 | PXD003306 | Pride
Mouse Podocyte Kidney 
TranscriptomicsDAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage [N2, daf-2, daf-16, daf-2;daf-16]
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates wi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-18 | E-GEOD-51162 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment to investigate the effect of inactivating the Apoptosis Antagonizing Transcription Factor (Aatf)
Human nephronophthisis and related ciliopathies suggest a link between ciliary signaling defects and altered DNA damage responses. The goal of our study is to elucidate the molecular link of both signaling systems as well as the role of altered DNA damage responses in kidney degeneration and fibrosi...
ORGANISM(S): Mus musculus 
2019-03-31 | E-MTAB-7077 | biostudies-arrayexpress
OtherComparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture.
Data from ProteomeXchange, PXD ID: PXD001005. Experiment: 130104MaRiS_TpD, file: 0089-130104MaRiS04TpD.mzml. Published as part of Proteomics. 2014 Nov 25 . From the Abstract: {{i}} Glomerular biology is dependent on tightly controlled signal transduction networks that control phosphorylation of sig...
ORGANISM(S): Rat 
GPM32320007078 | GPMDB
Resource Reanalysis 
UnknownTrafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.
Not available
S-EPMC549624 | biostudies-literature
UnknownAATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.
Not available
S-EPMC3474921 | biostudies-literature
TranscriptomicsAltered lipid metabolism in the aging kidney identified by three layered omic analysis
Aging-related diseases and their comorbidities affect the life quality of a constantly growing proportion of our population. Age-associated changes of kidney structure and function are considerable contributors to the dramatically increased incidence of chronic kidney disease world-wide which has be...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-74463 | biostudies-arrayexpress
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