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ProteomicsCardiac Atrial Compartmentalisation Proteomics: A Modified Density Gradient Method to Analyse Endo-lysosomal Proteins
Evidence that lysosomes are important in cardiac physiology and pathology is now emerging. We describe a label-free method suitable for small cardiac tissue biopsies based on a density-separated fractionation protocol, which allows us to study endo-lysosomal (EL) proteins in guinea pig atria. The t...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-09-09 | PXD021277 | Pride
Cardiac Rab proteins Lysosome Guinea-pig Lysosome storage disease Atria 
ProteomicsSerum autoantibodies to the glutamate receptor delta 2 in paediatric opsoclonus myoclonus ataxia syndrome
Abstract Objective: To identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome (OMAS) with contemporary antigen discovery methodology. Methods: OMAS patient serum IgG immunohistochemistry using age-equivalent rat cerebellar tissue was followed by immunoprecipitation, gel electro...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-07-30 | PXD009578 | Pride
Autoimmune  cerebellum  encephalitis  glud2  immunotherapy  opsoclonus myoclonus ataxia syndrome (omas)  neuroblastoma  paraneoplastic 
ProteomicsA TFEB nuclear export signal integrates amino acid supply and glucose availability
How cells coordinate the response to fluctuating carbon and nitrogen availability required to maintain effective homeostasis is a key issue. Amino acid limitation that inactivates mTORC1 promotes de-phosphorylation and nuclear translocation of Transcription Factor EB (TFEB), a key transcriptional re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD009677 | Pride
Glucose lysosome biogenesis running header: tfeb nuclear export Gsk3 Tfeb Nuclear export signal Mtor 
ProteomicsRegulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD026791 | Pride
Cyld phosphorylation and ub-binding 
ProteomicsBRAF/MAPK and GSK3 signaling converges to control MITF nuclear export
The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulatedin cancer. In principle, combinatorial posttranslational modification of key lineage specific transcription factors would be an effective mean stointegrate critical signaling events. U...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010782 | Pride
Mitf|melanoma|mapk|nuclear export|gsk3 
ProteomicsBRAF/MAPK and GSK3b signalling signaling converge to control MITF nuclear export
The close integration of the MAPK, PI3K and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial post-translational modification of key lineage–specific transcription factors would be an effective means to integrate critical signaling events....
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD010665 | Pride
Mitf | melanoma | mapk | nuclear export | gsk3b 
ProteomicsCompartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation
The emerging roles of endolysosomes (EL) in AF have yet to be discovered, especially how the EL contribute to the development of AF within a slow time frame. To identify the EL role in AF, we applied proteomics, transcriptomics, integrated analysis, electron tomography, western blotting and enzyme a...
ORGANISM(S): Capra hircus x Ovis aries 
2024-06-16 | PXD041056 | Pride
Endolysosomal protein Proteomics Atrial fibrillation Goat 
ProteomicsPleural fluid proteomics from patients with pleural infection shows signatures of diverse neutrophilic responses: The Oxford Pleural Infection Endotyping Study (TORPIDS 2)
Pleural infection is a severe and complicated disease with increasing incidence worldwide and is characterised by substantial associated morbidity and mortality.1,2 Although it is accepted that the disease is heterogeneous, and there is a validated clinical prediction score (RAPID)3,4, the biologica...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD054108 | Pride
Bacteriology Empyema Pleural infection Microbiology Pleural fluid 
ProteomicsGuillain-Barré syndrome following Zika virus infection is associated with a diverse spectrum of peripheral nerve reactive antibodies
Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurological side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4000 ZIKV cases. Whether the neurological symptoms of ZIKV infection are a consequenc...
ORGANISM(S): Rattus rattus (Black rat) Homo sapiens (Human) 
2023-03-10 | PXD028476 | Pride
Zika Guillain-barr Nerve 
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