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ProteomicsIdentification of non-overlapping functions between adaptor proteins NCK1 and NCK2
Signals from cell surface receptors are often relayed via adaptor proteins. NCK1 and NCK2 are Src-Homology (SH) 2 and 3 domain adaptors that regulate processes requiring a remodelling of the actin cytoskeleton. Evidence from gene inactivation in mouse suggest that NCK1 and NCK2 are functionally redu...
ORGANISM(S): Homo sapiens (Human) 
2018-09-20 | PXD008824 | Pride
Mass spectrometry Nck adaptors Specificity 
ProteomicsPolypharmacological perturbation of the 14-3-3 adaptor protein interactome stimulates neurite outgrowth
Targeting protein-protein interactions (PPIs) is a promising, but under-exploited, approach in the development of drugs for many indications. 14-3-3 proteins are a family of adaptor molecules with ubiquitous and critical functions in dozens of cell signaling networks. 14-3-3s bind to hundreds of ‘cl...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-03-31 | PXD017317 | Pride
Regeneration Axon 14-3-3 Rap1 Polypharmacology 
ProteomicsProximity labeling proteomics of the androgen receptor reveals Kruppel-Like Factor 4 as a repressor of androgen-dependent genes
Prostate cancer (PCa) is the most frequently diagnosed cancer in Canadian men and is the third cause of cancer mortality. PCa initiation and growth is driven by the androgen receptor (AR). AR is activated by androgens such as testosterone and controls prostatic cell proliferation and survival. We so...
ORGANISM(S): Homo sapiens (Human) 
2021-03-01 | PXD011974 | Pride
Ar Proximity Network Klf4 
ProteomicsAn Unbiased Strategy for Selecting Effective Combinations of Therapeutic Targets Supports the Development of a Novel Bispecific Antibody with Tumor-Suppressing Properties
Recent progress in dissecting molecular mechanisms essential for the survival and propagation of cancer cells triggered rapid development of targeted therapies. Although many of these therapies produce impressive initial responses in tumor suppression, the onset of resistance is practically unavoida...
ORGANISM(S): Homo sapiens (Human) 
2023-01-27 | PXD023034 | Pride
Bispecific anti-egfr/epha2 antibody  epha2 receptor  bioid  proximity proteomics 
ProteomicsProteomic analysis of the contribution of SH3 domains positioning to NCK2 interactome
This submission contains the mass spectrometry files for the manuscript by Ugo Dionne et al. that describes the functional characterization of NCK2 SH3 domains positions. To determine the contribution of NCK2 SH3 domains positioning to the protein interactions, we inter-changed the positions of its ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-12 | MSV000085092 | MassIVE
UnknownCOVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI - the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases.
Not available
S-EPMC9091487 | biostudies-literature
UnknownSeverity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: data from the French RMD COVID-19 cohort of 694 patients.
Not available
S-EPMC7712850 | biostudies-literature
UnknownCOVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study.
Not available
S-EPMC7993930 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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