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ProteomicsNerve activity inhibits mTORC1-dependent protein synthesis in skeletal muscle
To find out intracellular signaling pathways regulting fiber type specific muscle wasting we generated a new mouse model, which allows us to label specifically muscle proteins. Interestingly, we observed that loss of muscle activity by denervation induces a strong increase of protein labeling in oxi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056544 | Pride
Skeletal muscle Mtorc1 Protein synthesis 
ProteomicsRaptor and rapamycin dependent proteomic changes in Akt overexpressing skeletal muscle
Analysis of proteomic changes upon deletion of Raptor or inhibition by rapamycin in mouse muscles over expressing a constitutively active Akt.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-08 | PXD028796 | Pride
Akt Raptor Skeletal muscle Mtor 
TranscriptomicsThe FoxO signature in protein breakdown
Under stress conditions mammalian cells activate compensatory mechanisms to survive and maintain cellular function. During catabolic conditions, such as low nutrients, systemic inflammation, cancer or infections, protein breakdown is enhanced and aminoacids are released from muscles to sustain liver...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-52667 | biostudies-arrayexpress
ProteomicsResting skeletal muscle reduces ATP turnover during hibernation
In mammals, loss of food intake and reduced mechanical loading/activity of skeletal muscles leads to a very rapid loss in mass and function. However, during hibernation in bears, despite spending months without feeding and with very modest muscle activity, only moderate muscle wasting is observed. P...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2024-12-06 | PXD050980 | Pride
Bear Hibernation Skinned muscle fibers Single muscle fiber 
MetabolomicsLipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations an...
2019-01-07 | MTBLS750 | MetaboLights
TranscriptomicsMRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
The myogenic regulatory factor MRF4 is expressed at high levels in myofibers of adult skeletal muscle, but its function is unknown. Here we show that knockdown of MRF4 in adult muscle causes hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthes...
ORGANISM(S): Rattus norvegicus 
2016-07-15 | E-GEOD-67069 | biostudies-arrayexpress
TranscriptomicsCircadian transcriptome of fast tibialis anterior (TA) and slow soleus (SOL) skeletal muscles from muscle-specific Bmal1 KO and control Cre- littermates
To investigate the role of the circadian clock gene Bmal1 in skeletal muscle, we compared the circadian transcriptomes of fast tibialis anterior (TA) and slow soleus (SOL) skeletal muscles from muscle-specific Bmal1 KO (mKO) and their control Cre- littermates (Ctrl). Keyword: Circadian Transcriptome...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-43071 | biostudies-arrayexpress
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