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ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-08-25 | MSV000080100 | MassIVE
ProteomicsPalmitate suppresses CD8+ T cell antitumoral response by disrupting mitochondrial metabolism
Accumulation of lipids in the tumor microenvironment (TME) is a feature of several solid tumors and increased palmitate (PA) availability fosters tumor progression and metastases. The intrinsic effects of PA on cancer cells are well understood, but its role in modulating CD8+ T cells (CTL) functiona...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-20 | PXD046502 | Pride
Histone post-translational modifications Acetylation 
ProteomicsProMetheus: a database of hmSILAC-validated protein methylation sites
Protein arginine (R) methylation is a post-translational modification that has been shown to play a role in various biological processes, such as RNA splicing, DNA repair, immune response, signal transduction and tumor development. Here, we present a dataset of high-quality methylations obtained fro...
ORGANISM(S): Homo sapiens (Human) 
2022-06-02 | PXD027949 | Pride
Heavy methyl silac Silac Methylation 
ProteomicsSystematic analysis of the impact of R-methylation on RBPs-RNA interactions
RNA binding proteins (RBPs) bind RNAs through specific RNA-binding domains, generating multi-molecular complexes known as ribonucleoproteins (RNPs). Various post-translational modifications (PTMs) have been described to regulate RBP structure, subcellular localization and interactions with other pro...
ORGANISM(S): Homo sapiens (Human) 
2021-08-25 | PXD024601 | Pride
Prmts Oops R-methylation Rbps 
ProteomicsProteomics Profiling of Arginine Methylation Defines PRMT5 Substarate Specificity
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation, an abundant post-translational modification occurring on both chromatin-bound and cytoplasmic proteins. Growing evidence supports the involvement of PRMT5, the major Type II PRMT, in pro-survival and differentiation pathways,...
ORGANISM(S): Homo sapiens (Human) 
2019-04-10 | PXD009070 | Pride
Lc-ms Prmt5 Arginine methylation 
ProteomicsHistone post-translational modification analysis of Aspergillus strains
Chemical modifications of DNA and histone proteins impact the organization of chromatin within the nucleus. Changes in these modifications, catalyzed by different chromatin-modifying enzymes, influence chromatin organization, which in turn is thought to impact the spatial and temporal regulation of ...
ORGANISM(S): Aspergillus niger Neosartorya fumigata (Aspergillus fumigatus) Emericella nidulans (Aspergillus nidulans) 
2022-06-30 | PXD033478 | Pride
Aspergillus Histone post-translational modifications 
ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-10-14 | PXD002669 | Pride
Biomarker  epigenetics  ffpe  super-silac  cancer 
ProteomicsHistone PTM profiling during the cell cycle
To investigate how histone post-translational modifications (PTMs) change during the cell cycle, we profiled histone H3 and histone H4 in breast cancer and normal breast cell lines arrested in G1/S or G2/M phases.
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD013288 | Pride
Histone post-translational modifications Cell cycle Lc/ms Cell proliferation 
ProteomicsAlternative digestion approaches improve histone modification mapping by mass spectrometry in clinical samples
Profiling histone post-translational modifications (PTMs) in clinical samples holds great potential for the identification of epigenetic biomarkers and the discovery of novel epigenetic targets. We have recently developed a battery of mass spectrometry (MS)-based approaches to analyze histone PTMs i...
ORGANISM(S): Homo sapiens (Human) 
2010-10-08 | PXD009946 | Pride
Histone post-translational modifications Proteomics Epigenetics 
ProteomicsPRMT1-mediated methylation of the Large Drosha Complex regulates microRNA biogenesis
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Large Drosha Complex (LDC). Through high resolution mass spectrometry (MS) analysis we discovered that the LDC is extensively methylated, with 82 distinct methylated sites associated...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD011617 | Pride
Prmt1 Large drosha complex Mass spectrometry Microrna Protein methylation 
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