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ProteomicsNovel autoantibodies in rheumatoid arthritis using immunoprecipitation coupled with mass spectrometric analysis.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic joint inflammation resulting in progressive cartilage and bone destruction. In two thirds of early RA patients, rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPAs) are present. While these ant...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD069628 | Pride
Anti nuclear antibodies Mass spectrometry Ipms Rheumatoid arthritis Autoantibodies 
ProteomicsThe TFIID complex is a new autoantibody target in systemic sclerosis.
Systemic sclerosis (SSc) is characterized by systemic fibrosis, vascular dysfunction, and the presence of antinuclear autoantibodies. In up to 10% of persons with SSc, the target antigens of the antinuclear autoantibodies are unknown. Using IP-MS, we here describe another new target antigen in SSc. ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-01 | PXD064257 | Pride
Anti-nuclear autoantibodies Systemic sclerosis Ip-ms Tfiid Ana 
ProteomicsMass spectrometric analysis of Rheumatoid factor
Rheumatoid factor are autoantibodies that are found in +/- two thirds of patients with rheumatoid arthritis, a chronic autoimmune disease characterized by inflamed, swollen joints. They consist of polyclonal antibodies that target the Fc part of IgG. The antibodies are not highly specific for rheuma...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD063283 | Pride
Lc-ms/ms Immunoglobulins Rheumatoid factor Complementarity determining regions Isotypes 
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