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UnknownThe oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo.
Not available
S-EPMC4558118 | biostudies-literature
UnknownInhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines.
Not available
S-EPMC4494954 | biostudies-literature
TranscriptomicsTranscription profiling of rat colon from animals fed cellulose vs FOS diets and infected with Salmonella
To increase our knowledge of the effects of Fructo oligosaccharides (FOS) on Salmonella infection in fats, a controlle rat infection study was performed. Two groups of 12 rats were adapted for 14 days to a cellulose diet and one group of 12 rats to a FOS diet. One cellulose-fed group and the FOS-fed...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7472 | biostudies-arrayexpress
ProteomicsMethylome profiling of SetDB1 deficient ESCs reveals coordinated epigenetic cross-talk during pluripotency
In pluripotent mouse embryonic stem cells (ESCs), SetDB1, which targets up to twenty thousand genomic loci, plays an essential role in regulating various cellular processes, including maintenance of the embryonic stem cell state, differentiation and metabolism. SetDB1 is best known as a chromatin mo...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD074325 | Pride
Embryo Chep Epigenetics Conditional ko Escs Chromatin Setdb1 
ProteomicsMethylome profiling of SetDB1 deficient ESCs reveals coordinated epigenetic cross-talk during pluripotency
SetDB1 is best known as a chromatin modifier catalyzing H3K9me3. However, recent studies show that SetDB1 can mediate H3K27me3-deposition by PRC2, CTCF-binding, recruit DNA methyltransferases, and potentially regulate additional chromatin processes. To gain further insights, we profiled the protein ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-20 | PXD074363 | Pride
Hela Pulldown Epigenetics Co-immunoprecipitation Nuclear extract Gfp Chromatin Setdb1 
UnknownA Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors.
Not available
S-EPMC8161333 | biostudies-literature
GenomicsNitric oxide regulates gene expression in cancers by controlling histone posttranslational modifications [HiSeq 2000]
Dynamic changes in histone posttranslational modifications (PTMs) are important regulators of chromatin structure and gene transcription in both normal and disease settings. Herein, we describe a novel signaling mechanism of nitric oxide (•NO) by demonstrating its ability to modulate gene expressi...
ORGANISM(S): Homo sapiens 
2015-11-05 | E-GEOD-66318 | biostudies-arrayexpress
UnknownGrowth and gut comfort of healthy term infants exclusively fed with a partially hydrolysed protein-based infant formula: a randomized controlled double-blind trial.
Not available
S-EPMC11141394 | biostudies-literature
UnknownIDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas.
Not available
S-EPMC5418698 | biostudies-literature
TranscriptomicsTranscription profiling of rat colon mucosa at different time points following Salmonella infection
Salmonella enteritidis is suggested to translocate in the small intestine. Previously we identified that prebiotics, fermented in the colon, increased Salmonella translocation in rats, suggesting involvement of the colon in translocation. Effects of Salmonella on colonic gene expression in vivo are ...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7496 | biostudies-arrayexpress
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