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ProteomicsProteome of candida glabrata after Caspofungin exposure
Caspofungin resistance is a great concern, as the echinocandin drugs are recommended as first-line therapy for invasive candidiasis. Echinocandin resistance is conferred by mutations in FKS genes. Nevertheless, some pathways which regulate cellular stress responses could be crucial for enabling the ...
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2022-04-04 | PXD021578 | Pride
Lc ms/ms Candida glabrata Caspofungin Preteome 
MetabolomicsLimited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells, a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables the adaptation to these co...

2022-04-29 | MTBLS4722 | MetaboLights
ProteomicsUnc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma
Despite the availability of effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. To identify new therapeutic targets, we assessed RNA sequencing data from CD138+ MM patient cells (n = 813) across disease stages and found that an autophagy...
ORGANISM(S): Homo sapiens (Human) 
2026-05-27 | PXD067362 | Pride
Autophagy Ulk3 Interactome Multiple myeloma 
UnknownEmployment as HIV Prevention: An Employment Support Intervention for Adolescent Men Who Have Sex With Men and Adolescent Transgender Women of Color.
Not available
S-EPMC9377485 | biostudies-literature
UnknownVirtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
Not available
S-EPMC2884008 | biostudies-literature
ProteomicsPeriostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1
Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy and is caused by an repeat expansion [r(CUG)exp] located in the 3' untranslated region of the DMPK gene. Symptoms include skeletal and cardiac muscle dysfunction and fibrosis. In DM1, there is a lack of establi...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-02 | PXD024107 | Pride
Dm1 biomarker Dmsxl Dmpk Clinical proteomics Ctg-trinucleotide expansion Steinert’s disease 
ProteomicsElongator complex deficiency in sonic hedgehog medulloblastoma
Cancer genomics has illuminated a wide spectrum of genes and core molecular processes contributing to human malignancy. Still, the genetic and molecular basis of many cancers remains only partially explained. Genetic predisposition accounts for 5-10% of cancer diagnoses and genetic events cooperatin...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD016832 | Pride
Elongator complex Meduloblastoma Elp1 Shh 
UnknownGenome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.
Not available
S-EPMC10790310 | biostudies-literature
UnknownDe novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Not available
S-EPMC7007577 | biostudies-literature
UnknownEffect of Self-monitoring of Blood Pressure on Diagnosis of Hypertension During Higher-Risk Pregnancy: The BUMP 1 Randomized Clinical Trial.
Not available
S-EPMC9066279 | biostudies-literature
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