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ProteomicsCandida glabrata YPK2 is a multidrug susceptibility locus
The biological conservation between fungi and mammals has made development of selective antifungal drugs a difficult challenge. Further complicating this situation is the selection of antifungal drug-resistant organisms during drug treatment. The pathogenic yeast Nakaseomyces glabratus (called here ...
ORGANISM(S): [Candida] glabrata CBS 138 
2026-07-07 | PXD078067 | Pride
Candida glabrata Upc2a Ypk2 agc kinase Rna-seq Fluconazole 
TranscriptomicsNext Generation Sequencing identifies O2-responsive genes in the human pathogenic fungus Aspergillus fumigatus
Low oxygen conditions are not only common to natural environments but also occur during tissue invasive growth in the human host. Only few cellular factors have been identified up to now that allow the fungus to efficiently adapt its energy metabolism to the lack of O2. In the present study, we cult...
ORGANISM(S): Aspergillus fumigatus 
2014-07-25 | E-GEOD-55943 | biostudies-arrayexpress
ProteomicsDifferentiated PLB-985 cells as a model system for Aspergillus fumigatus infection
Fungal infections remain a tremendous source of global morbidity and mortality, with more than 1 billion individuals affected by fungal infections each year. Invasive infections are particularly dangerous and kill numbers on par with tuberculosis or malaria. Aspergillus fumigatus is a major source o...
ORGANISM(S): Aspergillus fumigatus CEA10 Homo sapiens (Human) 
2021-07-30 | PXD027032 | Pride
Extracellular vesicle Aspergillus fumigatus Plb-985 cells Size-exclusion chromatography Lc-ms/ms 
ProteomicsBiotinylated surfome profiling of A. fumigatus during early development
Aspergillus fumigatus is one of the most common airborne fungi that cause invasive mycoses in immunocompromised patients and also allergic diseases in immunocompetent individuals. In both cases, the surface proteins mediate the first contact with the human immune system to evade immune responses or ...
ORGANISM(S): Aspergillus fumigatus CEA10 
2020-04-22 | PXD018071 | Pride
Surface biotinylation Aspergillus fumigatus Allergens Surfome Lc-ms/ms 
ProteomicsFunctional characterization of the RNA interference pathway in A. fumigatus reveals its potential for antifungal therapy
The RNA interference (RNAi) pathway has evolved numerous functionalities in eukaryotes, with many on display in Kingdom Fungi. RNAi can regulate gene expression, facilitate drug resistance, or even be altogether lost to improve growth potential in some fungal pathogens. In the WHO fungal priority pa...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2023-02-17 | PXD039739 | Pride
Rna interference Aspergillus fumigatus Rna-based therapeutics Filamentous fungi Lc-ms/ms 
ProteomicsThe heat shock protein family A (HSPA8) acts as a surface receptor of alveolar macrophages specific for recognition and phagocytosis of Lichtheimia corymbifera spores
Mucormycosis is a life-threatening disease especially in immunocompromised patients that was caused my mucoralean fungi. The rate of mortality is tremendously increased in the last decades due to the lack of appropriate diagnostic tools, insufficient knowledge about the immune response toward the...
ORGANISM(S): Lichtheimia corymbifera JMRC:FSU:9682 Mus musculus (Mouse) 
2020-07-17 | PXD014197 | Pride
Hspa8 Mass spectrometry Alveolar macrophages Surface receptor Lichtheimia corymbifera Biotinylation 
ProteomicsFunctional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target
More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus. The azole class of antifungals represent first line therapeutics for most of these infections however resistance is rising. Identification of novel antifungal targets that, when inhibited, sy...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2024-04-09 | PXD042616 | Pride
Mass spectrometry Aspergillus fumigatus Phosphoproteomics Antifungal drug target Kinome 
ProteomicsPhosphoproteomic analysis of Arabidopsis root in response to cellooligomers (cellotriose)
Cellulose is the major polysaccharide in the primary and secondary cell wall. Its breakdown generates short-chain cellooligomers (COs) which induce Ca2+-dependent cell wall integrity (CWI) responses. Recently, a mutant (cork1) which did not respond to COs was identified. To find out the early phosph...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-09-23 | PXD033224 | Pride
Phosphoproteomics Cellooligomer Cellotriose Malectin Cell wall integrity 
ProteomicsProQ-associated small RNAs control motility in Vibrio cholerae
Gene regulation at the post-transcriptional level is prevalent in all domains of life. In bacteria, ProQ-like proteins have emerged as important RNA chaperones facilitating RNA stability and RNA duplex formation. In the major human pathogen V. cholerae, post-transcriptional gene regulation is key fo...
ORGANISM(S): Vibrio cholerae O1 biovar El Tor 
2025-01-06 | PXD055294 | Pride
In-gel digest Vibrio cholerae Bacteria Lc-ms/ms Flagellins 
ProteomicsPhagolysosomal proteomics identifies DHN-melanin-regulated processes in activated macrophage in response to Aspergillus fumigatus conidia
Infection by the human pathogenic fungus Aspergillus fumigatus is initialized by the outgrowth of asexual spores (conidia) into the lung tissue of the immunocompromised host following an inhalation of the airborne conidia. The resident phagocytes, the alveolar macrophages are the first immune cells ...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) Mus musculus (Mouse) 
2018-03-08 | PXD006134 | Pride
Host-pathogen interactions Aspergillus fumigatus Mycology Lc-ms Phagolysosome Dhn-melanin Macrophage Proteomics 
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