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Trypanosoma cruzi is the protozoan that causes Chagas disease, an endemic parasitosis in Latin America that has spread around the globe. Recently, a series of studies indicate that the gastrointestinal tract represents an important reservoir for T. cruzi in the chronic phase. It is also known that, ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Trypanosoma cruzi Dm28c Trypanosoma cruzi strain CL Brener 
2024-05-17 | PXD046906 | Pride
This project investigates the impact of N-myristoyltransferase (NMT) inhibition on the myristoylated proteome of Trypanosoma cruzi and human cardiomyocytes in the context of Chagas disease. Human AC16 cardiomyocytes were infected with T. cruzi (CL Brener strain) and treated with the reference NMT in...
ORGANISM(S): Trypanosoma cruzi Homo sapiens (Human) 
2026-01-26 | PXD071927 | Pride
We used a system based on the Tetracycline-inducible expression of the U-rich RNA-binding protein 1 (TcUBP1) and performed CRISPR/Cas9 targeting of TcUBP1 to monitor proteome changes in Trypanosoma cruzi cells expressing different levels of the protein.
ORGANISM(S): Trypanosoma cruzi strain CL Brener 
2024-01-02 | PXD047761 | Pride
These assays represent an antigen discovery screening, and epitope mapping characterization. In this screening two complete proteomes from Trypanosoma cruzi, from two different strains (CL-Brener, Sylvio X10), were displayed in the form of short peptides (tiling array, overlapped) and assayed with p...
ORGANISM(S): Homo sapiens 
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