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ProteomicsCross-Platform Evaluation Reveals Sample Preparation-Driven Biological Biases despite Advances in Mass Spectrometry Performance in Serum Proteomics
Advances in mass spectrometry (MS) instrumentation and protein extraction technologies are reshaping proteomics; however, whether improved analytical performance alters the biological information accessible from different sample preparation strategies remains unclear. Here, we performed a cross-plat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-11 | PXD078563 | Pride
Serum proteomics Reproducibility Quantitative accuracy Depth of proteome Orbitrap exploris 480 Bruker tims-tof ht Biomarker discovery 
ProteomicsQuantitative proteomic analyses of phage WCHPA-P1 infected Pseudomonas aeruginosa
This project aims to conduct a proteomic analysis of the infection of Pseudomonas aeruginosa strain by bacteriophage WCHPA-P1. The proteome of the host bacterium was examined at 20 minutes and 50 minutes post-infection with WCHPA-P1 phage.
ORGANISM(S): Pseudomonas aeruginosa 
2026-05-31 | PXD074315 | Pride
Pseudomonas aeruginosa strain  pseudomonas phage 
ProteomicsA c-di-AMP receptor mediates epithelial adhesion of Lactiplantibacillus plantarum
Cyclic di-adenosine monophosphate (c-di-AMP) is a crucial second messenger used by bacteria to mediate bacterial-host interactions. However, its roles in Lactiplantibacillus plantarum remain poorly understood. Here, we identify RwpL, which consists solely of an HTH domain, as a c-di-AMP receptor in ...
ORGANISM(S): Lactobacillus plantarum WCFS1 
2026-05-25 | PXD078286 | Pride
Colonization C-di-amp Lactiplantibacillus plantarum 
ProteomicsSildenafil Combined with Controlled Hypothermia Mitigates Microglial Activation After Neonatal Hypoxia-Ischemia in Rat.
The only validated treatment to prevent brain damage associated with hypoxia-ischemia (HI) encephalopathy of the newborn is controlled hypothermia with limited benefits. Additional putative neuroprotective drug candidates include sildenafil citrate, a phosphodiesterase-type 5 inhibitor. The main obj...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-30 | PXD045168 | Pride
Label free Hypoxia-ischemia Dia Microglia 
ProteomicsA new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis
Accounting for more deaths than any other bacterial species, Mycobacterium tuberculosis (Mtb) represents a critical threat to public health worldwide. A key factor contributing to Mtb's virulence is its unique cell envelope, which acts as a protective barrier. Among the components of this envelope, ...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 Bacteria 
2025-12-12 | PXD069594 | Pride
Marinum Mycobacterium Tuberculosis Lipoarabinomannan Arabinogalactan 
MetabolomicsUntargeted Metabolomics for Integrative Taxonomy: Metabolomics, DNA Marker-Based Sequencing, and Phenotype Bioimaging

Integrative taxonomy is a fundamental part of biodiversity and combines traditional morphology with additional methods such as DNA sequencing or biochemistry. Here, we aim to establish untargeted metabolomics for use in chemotaxonomy. We used three thallose liverwort species Riccia glauca

2026-01-30 | MTBLS4668 | MetaboLights
ProteomicsPML-driven sumoylation of PML::RARA-bound co-repressors drives immortalization of primary hematopoietic progenitors
While acute promyelocytic leukemia (APL) is always driven by fusions involving one of the three retinoic acid receptors, why PML and RARA are the preferred fusion partners has remained largely unsettled. Here we demonstrate that corepressor (NCoR) binding onto the RARA moiety of PML::RARA is require...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-04 | PXD078941 | Pride
Apl Pml::rara Sumo Ncor 
ProteomicsDemographic variables shape longitudinal proteome signatures of peripheral nerve injury in mice
Our comprehensive proteomic analysis of mouse sciatic nerves following Spared Nerve Injury (SNI) reveals new dimensions of the molecular mechanisms underlying peripheral nerve injury, shaped by sex, developmental stage, and progression over time. Building on our previous work profiling naïve sciatic...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-05 | PXD067006 | Pride
Sex-dependent Proteomics Peripheral nerve injury Age-dependent 
ProteomicsUnraveling the impact of VHL Exon 2 mutations identified in Erythrocytosis or von Hippel-Lindau disease, identified hnRNP F and hnRNP AB as new RNA-Binding Proteins involved in VHL splicing.
This study explores the impact of mutations in the exon 2 of the von Hippel-Lindau (VHL) gene, associated with erythrocytosis or von Hippel-Lindau disease. We analyzed 15 genetic variants, including missense and synonymous mutations, to assess their effects on VHL protein stability and splicing. Usi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-25 | PXD056515 | Pride
Dia Rna-binding proteins Von hippel-lindau disease Erythrocytosis 
ProteomicsColonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease
Secretory IgA (SIgA) is critical for maintaining the intestinal barrier. A dysregulated B-cell compartment and altered Ig secretion have been well documented in Crohn’s disease (CD) patients, although their origin is unknown. To unravel the role of mucosal humoral immunity in CD pathogenesis, we in-...
ORGANISM(S): Homo sapiens (Human) 
2026-01-13 | PXD069842 | Pride
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