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TranscriptomicsEnhancer Transcripts Mark Active Estrogen Receptor Binding Sites
In this study, we used Global Run-On sequencing (GRO-seq), a method that assays the genome-wide location and orientation of all active RNA polymerases. We generated a global profile of active transcription at ERM-NM-1 binding sites in MCF-7 human breast cancer cells in response to short time course ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-43835 | biostudies-arrayexpress
UnknownRed mark syndrome: Is the aquaculture water microbiome a keystone for understanding the disease aetiology?
Not available
S-EPMC10010170 | biostudies-literature
TranscriptomicsEnhancer Transcripts Mark Active Estrogen Receptor Binding Sites using GRO-seq
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43836 | biostudies-arrayexpress
TranscriptomicsEarly effects of cdkf;1 RNAPII CTD Serine-7 kinase mutation on regulation of transcription in 7 days old Arabidopsis seedlings
Serine phosphorylation of conserved Y1S2P3T4S5P6S7 repeats of RNA polymerase II carboxy-terminal domain (RNAPII CTD) plays a central role in the regulation of transcription and co-transcriptional RNA processing. Maintenance of CTD phosphoserine-7 mark in Arabidopsis requires the CDKF;1 kinase, which...
ORGANISM(S): Arabidopsis thaliana 
2011-08-31 | E-GEOD-27687 | biostudies-arrayexpress
TranscriptomicsBrd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release
Distal enhancers characterized by H3K4me1 mark play critical roles in developmental and transcriptional programs. However, potential roles of specific distal regulatory elements in regulating RNA Polymerase II (Pol II) promoter-proximal pause release remain poorly investigated. Here we report that a...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-51633 | biostudies-arrayexpress
ProteomicsAblation or Inhibition of Protein Disulfide Isomerase A3 (PDIA3) in Aberrant Club Cells Attenuates Osteopontin (SPP1) Production and Pulmonary Fibrosis
Rationale: The role of club cells in the pathology of Idiopathic Pulmonary Fibrosis IPF is not well understood. PDIA3, an endoplasmic reticulum (ER) based redox chaperone catalyzes the cysteine disulfide bonds (-S-S-) in various fibrosis-related proteins; however, mechanisms of action of PDIA3 in pu...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD021715 | Pride
Ipf Pdia3 Osteopontin Upr Pulmonary fibrosis Loc14 Spectral counting Ccsp Lc-ms/ms 
ProteomicsTargeting mitochondrial reactive oxygen species alleviates allergic airway disease in a mouse model of obese allergic asthma
Obesity is associated with severe, difficult to control asthma, and increased airway oxidative stress. Mitochondrial reactive oxygen species (mROS) are an important source of oxidative stress leading us to hypothesize that targeting mROS in obese allergic asthma might be an effective treatment strat...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2023-06-02 | PXD029715 | Pride
Obesity Mitochondrial reactive oxygen species (mros) Allergic asthma Airway oxidome Unfolded protein response (upr). Mitoquinone Tissue eosinophilia 
UnknownThe order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus.
Not available
S-EPMC7782583 | biostudies-literature
UnknownInhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.
Not available
S-EPMC8847543 | biostudies-literature
UnknownMitoquinone mesylate attenuates pathological features of lean and obese allergic asthma in mice.
Not available
S-EPMC9902225 | biostudies-literature
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