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ProteomicsThe Perijunctional Zone Is a Molecularly Distinct Muscle Subdomain Altered in Duchenne Muscular Dystrophy
The neuromuscular junction (NMJ) is a well-established model for synapse development, structure, and function. Surrounding the NMJ is a narrow perijunctional zone (PJZ), enriched in muscle-specific voltage-gated sodium channels that prevent synaptic fatigue. Despite this role, the PJZ remains poorly...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-27 | PXD067080 | Pride
Muscle proteomics Perijunctional zone Perilipin 4 Turboid Proximity labelling Duchenne muscular dystrophy Neuromuscular junction 
ProteomicsComposition and origin of lung fluid proteome in premature infants and relationship to respiratory outcome
We performed global proteomics of premature infant tracheal aspirate (TA) and plasma to determine the composition and source of lung fluid proteins and to identify potential biomarkers of respiratory outcome
ORGANISM(S): Homo sapiens (Human) 
2020-11-23 | PXD021966 | Pride
Tracheal aspirate Plasma Lung disease Premature infants 
Unknownp38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.
Not available
S-EPMC6894093 | biostudies-literature
ProteomicsKinase peptide discovery in MIB enriched samples using 2m monolithic silica-C18 column
This dataset accompanies our publication "An optimized chromatographic strategy for multiplexing in parallel reaction monitoring mass spectrometry: Insights from quantitation of activated kinases" in Molecular & Cellular Proteomics, 2016 (https://www.ncbi.nlm.nih.gov/pubmed/27940637). The submitted ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-10 | MSV000079644 | MassIVE
ProteomicsAffinity purification of biotinylated AtACINUS and Mass Spectrometric analysis to identify PTMs on AtACINUS
AtACINUS protein is involved in regulation of alternative transcription and splicing (AS). Previously we have identified O-GlcNAcylation and phosphorylation sites on AtACINUS using LWAC and IMAC enrichment (Xu et al., 2017). To identify more modification sites, we have created AtACINUS-YFP-TurboID/a...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-12-02 | PXD020749 | Pride
Seedling Acinus Plant Co-immunoprecipitation Arabidopsis thaliana atacinus O-glcnacylation Ip-ms Phosphorylation O-fucosylation Lc-ms/ms 
ProteomicsTMEM16K is an interorganelle regulator of endosomal sorting.
Using proximity biotinylation proteomics based on TMEM16K/Ano10 (an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia) BioID chimeras, we identify endosomal transport as a major functional cluster of interacting proteins.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-05-30 | PXD018990 | Pride
Bioid Endosomal sorting Tmem16k 
ProteomicsQuantitative phosphoproteomic analysis of the effect of deletion and duplication of the 16p11.2 genomic locus on induced pluripotent stem cells-derived neural progenitor cells
Deletion and duplication of the 16p11.2 genomic locus are associated with opposing changes in brain size. To determine cellular mechanisms that might underlie these opposing phenotypes, we performed quantitative phosphoproteomics on induced pluripotent stem cells (iPSC) derived neural progenitor cel...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD066614 | Pride
Taok2 Phosphorylation Neural progenitor cells Cilia length 
ProteomicsMapping Axon Initial Segment Structure and Function by Iterative Proximity Biotinylation
We constructed AIS-targeted biotin ligase by generating fusion proteins of BirA* with NF186, Ndel1, and Trim46; these chimeras mapped the molecular organization of intracellular membrane, cytosolic, and microtubule compartments of the AIS, respectively
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-13 | PXD016272 | Pride
Bioid Axon initial segments 
ProteomicsA novel translocon for biogenesis of multi-pass membrane proteins
A novel 370 kDa translocon comprising Sec61 and five accessory factors acting co-translationally with ribosomes to fold and insert multi-pass membrane proteins was identified, purified and analyzed structurally by single particle cryo-EM and cross-linking mass spectrometry. The purified ribosome-tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-08 | MSV000084065 | MassIVE
ProteomicsCharacterizing protein phosphorylation downstream of the TrkA receptor
Phosphorylation twenty minutes after stimulation of the TrkA receptor was characterized in PC12 (rat) cells. The study was performed using chimeric receptors, where the endodomain of TrkA was fused to the extracellular domain of PDGFR. As PDGFR (and PDGF) are not expressed in these cells, addition ...
2013-07-11 | MSV000078461 | MassIVE
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