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ProteomicsNucleophosmin sustains WNT-driven cell proliferation and tumour initiation in vivo
Nucleophosmin (NPM1) is a nucleolar protein frequently mutated in haematopoietic malignancies and overexpressed in many solid tumours, but little is known about its functional role in carcinogenesis. Here, we identify NPM1 as a commonly upregulated gene following APC loss in tissues that positively ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-12 | PXD062969 | Pride
Nucleophosmin Wnt signalling Tmt16plex Colorectal cancer 
ProteomicsIdentifying mTOR regulated RNA binding proteins
To investigate the RNA binding proteins that change following mTOR inhibition, HeLa cells were treated with and without 200nM Torin1 for an hour. Cells were the UV254 cross-linked, lysed and large scale whole cell oligo(dT) based pulldowns were performed with identification and quantification of pu...
ORGANISM(S): Homo sapiens (Human) 
2020-11-24 | PXD016705 | Pride
Nanoflow. Larp1 Mtor Synapt g2s Rna-binding proteins 
ProteomicsRNA helicase EIF4A1-mediated translation is essential for the GC response
EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5’ untranslated regions. However, very little is known of their roles in non-malignant cells. Using mouse models to d...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-09 | PXD046710 | Pride
Eif4a1 B cells Translation 
UnknownDownregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms.
Not available
S-EPMC3986586 | biostudies-literature
UnknownA common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.
Not available
S-EPMC4579346 | biostudies-literature
GenomicsIn vivo CRISPR/Cas9 screen to identify candidate therapeutic gene targets to enhance docetaxel efficacy in prostate cancer
Docetaxel chemotherapy in metastatic prostate cancer offers only a modest survival benefit due to emerging resistance. To identify candidate therapeutic gene targets, we applied a murine prostate cancer orthograft model that recapitulates clinical invasive prostate cancer in a genome-wide CRISPR/Cas...
ORGANISM(S): Mus musculus 
2020-10-07 | E-MTAB-9482 | biostudies-arrayexpress
ProteomicsPBANKA_0828000 interactome proteomics
PBANKA_0828000 was identified in a screen for sex determination genes in Plasmodium berghei. PBANKA_0828000 encodes a zinc finger protein of unknown function. To address its role, PBANKA_0828000 was tagged with an HA tag at the endogenous locus, and protein interactions were characterised by affinit...
ORGANISM(S): Plasmodium berghei 
2023-02-22 | PXD033827 | Pride
Pbanka_0828000 Plasmodium berghei 
UnknownSustained translational repression by eIF2α-P mediates prion neurodegeneration.
Not available
S-EPMC3378208 | biostudies-literature
ProteomicsYeast phosphofructokinase subunit 2 has ATP-dependent RNA unwinding activity and modulates cell cycle progression
Phosphofructokinase (PFK) is a rate-limiting glycolytic enzyme that also possesses an unexplored polyadenylated RNA binding activity. Here, we show that the two PFK subunits, Pfk1 and Pfk2, in budding yeast bind a large number of mRNAs in cells, including ones coding for proteins involved in regulat...
ORGANISM(S): Saccharomycetales (ncbitaxon:4892) 
2024-12-04 | MSV000096586 | MassIVE
TranscriptomicsTranslational profiling of HEK293 cells exposed to cold shock (32 degrees C) and untreated (37 degrees C)
This experiment investigates the effect of mild cold-shock (32 degrees C, 24 hours) on the translatome of human HEK293 cells. After cold-shock, cells were treated with cycloheximide to block elongation, then sucrose density gradients were used to separate post-nuclear extracts into polysome and subp...
ORGANISM(S): Homo sapiens 
2017-02-23 | E-MTAB-5437 | biostudies-arrayexpress
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