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ProteomicsMulti-omics data integration reveals correlated regulatory features of triple negative breast cancer
Triple negative breast cancer is an aggressive type of breast cancer with very little treatment options. TNBC is very heterogeneous with large alterations in the genomic, transcriptomic, and proteomic landscapes leading to various subtypes with differing responses to therapeutic treatments. We appli...
ORGANISM(S): Homo sapiens (Human) 
2021-06-24 | PXD025238 | Pride
Multi-omics data integration Phosphoproteomics Triple negative breast cancer Histone posttranslational modification Rna-seq 
ProteomicsQuantitative histone mass spectrometry identifies elevated histone H3 lysine 27 trimethylation in melanoma
Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulation of gene transcription and diseases such as cancer...
ORGANISM(S): Homo sapiens (Human) 
2015-12-02 | PXD002471 | Pride
Human Runx3 Histone h3 lysine 27 trimethylation Melanoma Ezh2 
ProteomicsQuantitative histone mass spectrometry identifies elevated histone H3 lysine 27 trimethylation in melanoma
Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulation of gene transcription and diseases such as cancer...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079979 | MassIVE
ProteomicsProteomic Analysis of Canine Hepatobiliary Neuroendocrine Neoplasms
Neuroendocrine neoplasms of the gallbladder and liver occur rarely in dogs and humans. A recent reclassification of human neuroendocrine neoplasms by the World Health Organization has refined categorization of these tumors by morphology, replicative indices, and molecular signatures. In humans, thes...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2023-03-11 | PXD028822 | Pride
Neurouro 
ProteomicsSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection of Jamaican Fruit Bat Intestinal Epithelial Cells Induces Robust Interferon Activation
Bats are the most important natural reservoirs for a variety of emerging viruses that cause several illnesses in humans and other mammals. Increased viral shedding by bats is thought to be linked to an increased ability of many bat species to tolerate viral infection. The severe acute respiratory sy...
ORGANISM(S): Artibeus jamaicensis 
2024-01-26 | PXD036016 | Pride
Sars-cov-2 Dia Interferon Jamaican fruit bats 
ProteomicsA phase separation mechanism underlies development of cancer and aberrant organization of three-dimensional chromatin structure
Development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human hematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP214) generates an aberrant chimera that invariably retains...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD023548 | Pride
Oncogenesis Homeodomain-containing transcription factor Intrinsically disordered regions (idrs) Bioid 
ProteomicsBAHCC1 binds H4K20me1 to facilitate the MCM complex loading for DNA replication
Methylation of histone H4 lysine 20 (H4K20), such as H4K20 mono-methylation (H4K20me1), regulates the biological processes of DNA replication, cell cycle progression, and DNA damage repair1-4. Whereas H4K20me1 is knowingly written by SET85,6 (also known as PR-Set7) and erased by PHF87 (also known as...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD036436 | Pride
Bioid Gelc Human Nsaf 
ProteomicsZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM confers primary murine hematopoietic stem/progenitor c...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-21 | PXD023702 | Pride
Acute myeloid leukemia H3k36me3 Bromodomain 
ProteomicsComprehensive Proteogenomic Analysis of the Anti-tumor Immunoactivity of a Novel Oncolytic Vesiculovirus in Hepatocellular Carcinoma
Oncolytic viruses can effectively unwrap a multimodal anti-tumor activity, encompassing a selective tumor cell killing and promoting a systemic anti-tumor immunity, making them a formidable foe against cancer. Among these, several members of the Rhabdoviridae family are particularly attractive as on...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD035806 | Pride
Rhabdoviruses  hepatocellular carcinoma  jurona virus  oncolytic virotherapy 
ProteomicsIP-to-MS: an unbiased workflow for antigen profiling
Immunoprecipitation is among the most widely utilized methods in biomedical research, with applications that include the identification of antibody targets and associated proteins. The path to identifying these targets is not straightforward, however, and often requires the use of chemical crosslink...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056617 | Pride
Autoimmune disease Mass spectrometry Unbiased antigen identification Immunoprecipitation 
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