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ProteomicsOptimized MeOH/MTBE-based Protein Precipitation and Lipid Removal Enables High Enrichment of Low Molecular Weight Peptides and Proteins from Human Plasma
Low molecular weight (LMW) peptides and proteins (LMWPs, < 30 kDa) in human plasma, serving as potential biomarkers or drug targets, are endowed with a wealth of biological and clinical research values. However, the extraction of LMW species is retarded by high-abundance proteins (HAPs) and therein ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD016957 | Pride
Human Plasma Lc-ms/ms 
ProteomicsStructural complementarity offsets low receptor affinity in E7820-mediated RBM39 degradation by CRL4DCAF15
The investigational drugs E7820, indisulam and tasisulam (aryl-sulfonamides) promote the degradation of the splicing factor RBM39 in a proteasome and CRL4DCAF15 ubiquitin ligase-dependent mechanism, however the molecular details of this activity remain elusive. Here we present the cryo-EM structure ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-10 | PXD014536 | Pride
Dcaf15 E7820 Crl4 Sulfonamide Ubiquitin Cullin Rbm39 
UnknownFunctional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element.
Not available
S-EPMC8322933 | biostudies-literature
UnknownAssociation of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.
Not available
S-EPMC6374980 | biostudies-literature
UnknownHair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes.
Not available
S-EPMC5703444 | biostudies-literature
UnknownIdentification of common genetic risk variants for autism spectrum disorder.
Not available
S-EPMC6454898 | biostudies-literature
UnknownImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Not available
S-EPMC9793579 | biostudies-literature
UnknownThe power of genetic diversity in genome-wide association studies of lipids.
Not available
S-EPMC8730582 | biostudies-literature
UnknownMapping the genetic landscape across 14 psychiatric disorders.
Not available
S-EPMC12779569 | biostudies-literature
UnknownCost-effectiveness of Aflibercept Monotherapy vs Bevacizumab First Followed by Aflibercept If Needed for Diabetic Macular Edema.
Not available
S-EPMC9896372 | biostudies-literature
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