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ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17. Evaluation of heparin effects on sample preparation by FASP.
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-23 | PXD054987 | Pride
Sheddome Adam17 Ectodomain shedding Disintegrin metalloproteinases Secretome 
ProteomicsiRhom2 regulates HMGB1 secretion to modulate inflammation and hepatocyte senescence in an in vitro model of ischemia/reperfusion injury
Background and Aims: Ischemia/reperfusion injury (IRI), considered one of the most important causes of liver organ rejection in acute and chronic phases, generates an inflammatory environment leading to compromised allograft functionality and rejection. In the last ten years, iRhom2 emerged as an es...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD046469 | Pride
Liver transplant  ischemia/reperfusion  inflammation  irhom2  hmgb1  cellular senescence  secretomics. 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17 - Evaluation of heparin effects on sample preparation PreOmics
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055002 | Pride
Sheddome Adam17 Ectodomain shedding Heparin Disintegrin metalloproteinases Secretome 
ProteomicsProteomic analysis and functional validation reveal distinct therapeutic capabilities related to priming of mesenchymal stromal/stem cells with IFN-γ and hypoxia: potential implications for their clinical use
Mesenchymal stromal/stem cells (MSCs) are a heterogeneous population of multipotent cells that can be obtained from various tissues, such as dental pulp, adipose tissue, bone marrow and placenta. MSCs have gained importance in the field of regenerative medicine because of their promising role in cel...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD052445 | Pride
Msc priming Msc therapeutic properties Proteomic analysis Msc paracrine effects Placenta-derived mesenchymal stromal/stem cells Ifn-γ priming Hypoxia priming 
ProteomicsIdentification of membrane proteins regulated by ADAM15 by SUSPECS proteomics
ADAM15 is a member of the disintegrin-metalloproteinase family of sheddases, which plays a role in several biological processes including cartilage homeostasis. In contrast with well-characterized ADAMs, such as the canonical sheddases ADAM17 and ADAM10, little is known about substrates of ADAM15 or...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD042358 | Pride
Chondrocytes Proteomics Osteoarthritis Mass spectrometry-lc-ms/ms Adams Specs Adam15 Metalloproteases 
UnknownPersonalizing Cancer Pain Therapy: Insights from the Rational Use of Analgesics (RUA) Group.
Not available
S-EPMC8119556 | biostudies-literature
UnknownSearch for supersymmetry in pp collisions at [Formula: see text] TeV in events with a single lepton, jets, and missing transverse momentum.
Not available
S-EPMC4370766 | biostudies-literature
UnknownMeasurement of the differential cross section for top quark pair production in pp collisions at [Formula: see text].
Not available
S-EPMC4657759 | biostudies-literature
UnknownSearch for heavy neutrinos and [Formula: see text] bosons with right-handed couplings in proton-proton collisions at [Formula: see text].
Not available
S-EPMC4371073 | biostudies-literature
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