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ProteomicsCancer cell-derived ADAM15 dictates macrophage infiltration in colorectal tumors
Tumor progression and response to treatment is highly affected by interactions between cancer cells and the tumor microenvironment (TME). Many of the soluble factors and signaling receptors involved in this crosstalk are shed by a disintegrin and metalloproteinases (ADAMs). Upregulation of ADAM15 ha...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-24 | PXD041164 | Pride
Lc-msms Cyr61 Mouse Tmt Ct26 Adam15 
ProteomicsSurface Proteomics of ADAM15 Knock-Down cells
ADAM15 is a member of the disintegrin-metalloproteinase family of sheddases, which plays a role in several biological processes including cartilage homeostasis. Contrary to well-characterized ADAMs, little is known about ADAM15 substrates or how the enzyme exerts its biological functions. Herein, we...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD042402 | Pride
Surface Adam15 Suspecs 
ProteomicsLoss of ADAM15 exacerbates transition to decompensated hypertrophy through activation of calcineurin pathway
Label-free quantification of cardiac tissue following transverse aortic constriction (TAC) in a WT and ADAM15-/- mouse model.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-03-07 | MSV000089016 | MassIVE
ProteomicsIdentification of membrane proteins regulated by ADAM15 by SUSPECS proteomics
ADAM15 is a member of the disintegrin-metalloproteinase family of sheddases, which plays a role in several biological processes including cartilage homeostasis. In contrast with well-characterized ADAMs, such as the canonical sheddases ADAM17 and ADAM10, little is known about substrates of ADAM15 or...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD042358 | Pride
Chondrocytes Proteomics Osteoarthritis Mass spectrometry-lc-ms/ms Adams Specs Adam15 Metalloproteases 
UnknownPotential role for ADAM15 in pathological neovascularization in mice.
Not available
S-EPMC166329 | biostudies-literature
UnknownIdentification of membrane proteins regulated by ADAM15 by SUSPECS proteomics.
Not available
S-EPMC10304831 | biostudies-literature
UnknownADAM15 correlates with prognosis, immune infiltration and apoptosis in hepatocellular carcinoma.
Not available
S-EPMC8436918 | biostudies-literature
UnknownADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells.
Not available
S-EPMC6715704 | biostudies-literature
UnknownADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions.
Not available
S-EPMC3375543 | biostudies-literature
UnknownADAM15 Participates in Tick-Borne Encephalitis Virus Replication.
Not available
S-EPMC7851565 | biostudies-literature
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