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ProteomicsAssembly of respiratory complex I is regulated by FMN insertion into the N-module.
Respiratory complex I plays a crucial role in the mitochondrial electron transport chain and shows promise as a therapeutic target for various human diseases. While most studies focus on inhibiting complex I at the Q-site, little is known about inhibitors targeting other sites within the complex. In...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD047527 | Pride
Human nmodule 
ProteomicsChaperonin CCT controls cell fuelling by lipids and extracellular vesicle production through kinesin dynamics
Please provide an overall description of your study, think something similar in scope to the manuscript abstractCell proteostasiCell proteostasis includes gene transcription, protein translation, folding of de novo proteins, post-translational modification, secretion, degradation and recycling. By p...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD034917 | Pride
Extracellular vesicle Lipidomic Peroxisome Cct Lipid droplet Chaperonin 
ProteomicsMechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD025910 | Pride
Human cells Stretching 
ProteomicsNature Communications manuscript NCOMMS-22-26923A
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. Nature Communications manuscript NCOMMS-22-26923A
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-10-24 | PXD043016 | Pride
Lcms raw files 
ProteomicsLoss of mitochondrial complex II causes severe respiratory chain dysfunction
Mitochondrial complex II (succinate dehydrogenase, SDH) links the tricarboxylic acid cycle to the respiratory chain. To investigate how disruption of complex II affects mitochondrial respiratory organization, we generated cell lines lacking either SDHA or SDHB and systematically characterized the ac...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD076790 | Pride
Respiratory chain Complex ii 
ProteomicsDiferential expression analyses PLAC8 defective cells
SARS-CoV-2 pandemic has caused a dramatic health, social and economic crisis worldwide. To better understand the host-virus interactions and identify potentially targetable host factors, we have conducted CRISPR-Cas9 genetic screens using SARS-CoV-2 pseudotyped lentiviruses on human lung cancer cell...
ORGANISM(S): Homo sapiens (Human) 
2022-09-06 | PXD036334 | Pride
Plac8 Covid 
ProteomicsMitochondria facilitate their own removal by expanding the macrophage pool
Specialized tissues demand support for long-term fitness. In the heart, for example, the removal of spent mitochondria by macrophages is critical for cardiac function. In an organismal-wide screening, we show here that the transfer of mitochondria to macrophages is prominent in other organs that rel...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-02 | PXD053573 | Pride
Mitochondria Macrophage 
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
UnknownBaseline Characteristics of Fabry Disease "Amenable" Migalastat Patients in Argentinian Cohort.
Not available
S-EPMC10896645 | biostudies-literature
UnknownEffectiveness of a smartphone application for improving healthy lifestyles, a randomized clinical trial (EVIDENT II): study protocol.
Not available
S-EPMC4003852 | biostudies-literature
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